Results 221 to 230 of about 728,551 (263)

Effect of bioavailability on Dose-Response relationships

The American Journal of Medicine, 1984
To achieve the goals of drug therapy one must not only select the appropriate drug but also ensure that it is administered in the proper dose. Sufficient drug should be administered to achieve a therapeutic effect, yet not so much as to produce unwanted side effects.
openaire   +2 more sources

Nonparametric Analysis of Dose‐Response Relationships

Annals of the New York Academy of Sciences, 1999
Abstract: A nonparametric method, isotonic regression, is proposed for analyzing a dose‐response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required, the only assumption is monotonicity ...
openaire   +2 more sources

Dose-response relationships with antihypertensive drugs

Pharmacology & Therapeutics, 1992
A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
openaire   +2 more sources

Dose-response relationship in clinical oncology

Plastic and Reconstructive Surgery, 1985
The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment ...
openaire   +2 more sources

Dose-Response Relationships

Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold ...
openaire   +1 more source

Dose-Response Relationship of a Uricosuric Diuretic

1977
Hyperuricaemia is a common complication of diuretic use in man and its simple elimination as a side effect would be an advantage. The finding that the indanone diuretic, MK-196, was actually uricosuric in the chimpanzee (Fanelli et alii, 1974), was of potential importance to human therapeutics.
B T, Emmerson, L, Thompson, K, Mitchell
openaire   +2 more sources

Dose-response relationship of phototherapy

The Journal of Pediatrics, 1978
L Ballowitz, G. Geutler, J. Krochmann
openaire   +2 more sources

Models of Dose Response Relationships

Health Physics, 2020
openaire   +2 more sources

Dose-Response Relationship

2023
John Timbrell, Frank A. Barile
openaire   +1 more source

Estrogen dose-response relationship

Clinical Pharmacology and Therapeutics, 1987
openaire   +2 more sources