Results 101 to 110 of about 5,610,097 (285)

Maxwell Spectrum as a Parameter to Verify the Dose in Brain Cancer (Glioblastoma) by Boron Neutron Capture Therapy (BNCT) using Monte Carlo Method

Brazilian Journal of Radiation Sciences
To evaluate the efficiency of neutron capture therapy (BNCT) treatment in glioblastoma multiforme, it is necessary to evaluate the impact of the neutron beam on the tumor cell and find better results so that BNCT treatment is viable.
Otto Haubrich, Domingos D'Oliveira Cardoso, Marcos Paulo Cavaliere de Medeiros   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Expected Usefulness of Fourth Dose of COVID-19 Vaccine for Patients with Underlying Solid Tumor who Previously Received the Primary Heterologous COVID-19 Vaccine

Indian Journal of Medical and Paediatric Oncology
Coronavirus disease 2019 (COVID-19) immunization frequently requires two standard doses. Due to the likelihood that the population may lose immunity after receiving a standard mass vaccination and the potential for the introduction of a new strain ...
Sora Yasri, Viroj Wiwanitkit
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

High-dose versus low-dose block-and-replace treatment for a first episode of Graves’ disease

European Thyroid Journal
Objective: The optimal treatment with antithyroid drugs (ATDs) for a first episode of Graves’ disease (GD) remains controversial. Methods: Retrospective, two academic centres study of newly diagnosed GD between 1990 and 2022, treated with ATD in block ...
Arnaud Smolders, Aglaia Kyrilli, Stefan Matei Constantinescu, Bernard Corvilain, Chantal Daumerie, Maria-Cristina Burlacu   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A Database for Estimating Organ Dose for Chest and Head CT Scans for Arbitrary Spectra and Angular Tube Current Modulation [PDF]

, 2012
Purpose: The purpose of this study was to develop a database for estimating organ dose in a voxelized patient model for coronary angiography and brain perfusion CT acquisitions with any spectra and angular tube current modulation setting.
Badal, Andreu, Kyprianou, Iacovos, Rupcich, Franco, Schmidt, Taly Gilat   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluation of the absorbed dose in X-ray microtomography [PDF]

, 2015
It is widely known that a sample receives a radiation absorbed dose during a CT-scan. Although this can have unwanted effects on the sample such as discolouration, little can be found in literature about the absorbed dose in micro-CT applications (except
Bacher, Klaus, Bonte, Stijn, De Muynck, Amélie, Dhaene, Jelle, Dierick, Manuel, Van Hoorebeke, Luc   +5 more
core