Results 61 to 70 of about 365,633 (275)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dose coefficients for the ICRP pediatric mesh-type reference computational phantoms under idealized external photon exposure geometries

Nuclear Engineering and Technology
The International Commission on Radiological Protection (ICRP) recently released the pediatric mesh-type reference computational phantoms (MRCPs) through ICRP Publication 156 to overcome the limitations of the pediatric voxel-type reference computational
Chansoo Choi, Bangho Shin, Yeon Soo Yeom, Wesley E. Bolch, Chan Hyeong Kim   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Bismuth-silicon and bismuth-polyurethane composite shields for breast protection in chest computed tomography examinations

Journal of Medical Physics, 2018
The article aims at constructing protective composite shields for breasts in chest computed tomography and investigating the effects of applying these new bismuth composites on dose and image quality.
Parinaz Mehnati, Mehran Arash, Parisa Akhlaghi   +2 more
doaj   +1 more source

Response of Photon Dosimeters and Survey Instruments to New Operational Quantities Proposed by ICRU RC26

, 2018
Operational quantities in radiation protection are defined as conservative estimates of the protection quantities, which are generally not accessible to measurement.
Otto, Thomas
core   +1 more source

GEANT4 for breast dosimetry: parameters optimization study [PDF]

, 2015
Mean glandular dose (MGD) is the main dosimetric quantity in mammography. MGD evaluation is obtained by multiplying the entrance skin air kerma (ESAK) by normalized glandular dose (DgN) coefficients.
Fedon, C., Longo, F., Longo, R., Mettivier, G.   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dose coefficients for ICRP pediatric mesh-type reference computational phantoms under idealized external electron exposures

Nuclear Engineering and Technology
In the present study, a comprehensive dataset of dose coefficients for idealized external electron exposures has been established using the newly released ICRP-156 pediatric mesh-type reference computational phantoms (MRCPs) in conjunction with the ...
Chansoo Choi, Bangho Shin, Sungho Moon, Yeon Soo Yeom, Chan Hyeong Kim, Wesley E. Bolch   +5 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Determination of the conversion coefficients from the dose-length product to the effective dose for CT-examinations of the whole body including lower extremitie

Радиационная гигиена
Today in the Russian Federation, the existing method for assessing patients` effective doses during computed tomography in the form of conversion coefficients from the dose-length product provides for the area from the head to the upper third of the ...
P. S. Druzhinina, L. A. Chipiga, A. V. Vodovatov, I. V. Soldatov, Z. A. Lantukh, K. V. Tolkachev   +5 more
doaj   +1 more source