Results 171 to 180 of about 233,485 (260)

Explainable machine learning for patient-specific quality assurance in intensity-modulated radiotherapy based on anatomical structures. [PDF]

J Appl Clin Med Phys
Zhang X, Huang Y, Wang J, Zhang X, Chen H, Luo Y, Xie J, Xu Z, Xu Y.   +8 more
europepmc   +1 more source

Dose dependence of intratumoral perivascular distribution of monoclonal antibodies. [PDF]

J Pharm Sci, 2012
Rhoden JJ, Wittrup KD.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

In-vivo dosimetry using electronic portal imaging in online-adaptive radiotherapy for rectal cancer. [PDF]

Phys Imaging Radiat Oncol
Razinskas G, Schindhelm R, Richter A, Kraft J, Zimmermann M, Tamihardja J, Wittig-Sauerwein A, Wegener S.   +7 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

From Platelet Toxicity to Precision Targeting: Evolving Strategies to Overcome Thrombocytopenia in BCL-2/BCL-XL Inhibition. [PDF]

Health Sci Rep
Mohiuddin M.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Orexin System Modulates Stress-Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence. [PDF]

Addict Biol
He W, Hu A, Zhao T, Deng L, Wu H, Xiang X.   +5 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Epidemiological impacts of nonpharmaceutical interventions are modulated by immunity exposure trade offs. [PDF]

Commun Med (Lond)
Saad-Roy CM, Nielsen BF, Lind ML, Wagner CE, Traulsen A, Metcalf CJE, Boots M, Cummings DAT, Grenfell BT.   +8 more
europepmc   +1 more source