Results 41 to 50 of about 1,206,776 (294)

A multicentre, open-label, phase-I/randomised phase-II study to evaluate safety, pharmacokinetics, and efficacy of nintedanib vs. sorafenib in European patients with advanced hepatocellular carcinoma [PDF]

, 2018
Background: This multicentre, open-label, phase-I/randomised phase-II trial evaluated safety, pharmacokinetics, maximum-tolerated-dose (MTD) per dose-limiting toxicities (DLTs), and efficacy of nintedanib vs.
Deptala, A, Fartoux, L, Graham, J, Hocke, J, Loembé, A-B, Ma, Y T, Meyer, T, Palmer, D H, Peck-Radosavljevic, M, Ross, P, Schnell, D, Studeny, M   +11 more
core   +3 more sources

The efficacy and tolerability of bortezomib, thalidomide, and dexamethasone induction therapy with a thalidomide dose step‐up strategy in patients with newly diagnosed multiple myeloma: A prospective observational study

Cancer Reports
Background Thalidomide‐containing regimens cause adverse events (AEs) that may require a reduction in treatment intensity or even treatment discontinuation in patients with multiple myeloma. As thalidomide toxicity is dose‐dependent, identifying the most
Po‐Wei Liao, Hsueh‐Ju Lu, Tsung‐Chih Chen, Hsin‐Chen Lin, Yu‐Hsuan Shih, Chieh‐Lin Jerry Teng   +5 more
doaj   +1 more source

Challenge Level Contributes to the Efficacy of Treadmill Interventions after Stroke: A Systematic Review and Meta-Analysis

Brain Sciences, 2023
Intervention parameters such as the challenge, amount, and dosage (challenge × amount) have the potential to alter the efficacy of rehabilitation interventions after stroke.
Sharon Olsen, Gemma Alder, Usman Rashid, Emeline Gomes, Madeleine Aislabie, Fran Chee, Caitlin Smith, Brody Kean, Nicola Towersey, Nada Signal   +9 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Post hoc analysis of reactogenicity trends between dose 1 and dose 2 of the adjuvanted recombinant zoster vaccine in two parallel randomized trials

Human Vaccines & Immunotherapeutics, 2020
In two large clinical trials (ZOE-50 [NCT01165177] and ZOE-70 [NCT01165229]), two doses of the adjuvanted recombinant zoster vaccine (RZV) demonstrated >90% efficacy against herpes zoster in adults ≥50 years of age.
Romulo Colindres, Valentine Wascotte, Alain Brecx, Christopher Clarke, Caroline Hervé, Joon Hyung Kim, Myron J. Levin, Lidia Oostvogels, Toufik Zahaf, Anne Schuind, Anthony L. Cunningham   +10 more
doaj   +1 more source

A dose-response characterization of transcranial magnetic stimulation intensity and evoked potential amplitude in the dorsolateral prefrontal cortex

Scientific Reports, 2023
By combining transcranial magnetic stimulation (TMS) with electroencephalography, human cortical circuits can be directly interrogated. The resulting electrical trace contains TMS-evoked potential (TEP) components, and it is not known whether the ...
Louisa Krile, Elnaz Ensafi, Jaeden Cole, Mah Noor, Andrea B. Protzner, Alexander McGirr   +5 more
doaj   +1 more source

Imaging Studies of photodamage and self-healing in disperse orange 11 dye-doped PMMA

, 2011
We report on optical imaging studies of self-healing after laser-induced photodamage in disperse orange 11 dye doped into poly(methyl methacrylate) (PMMA) polymer.
Abbas, Benjamin Anderson, Chu, Embaye, Howell, Howell, Mark G. Kuzyk, Norwood, Peng, Shiva K. Ramini, Vigil, Wang, Zhu, Zhu   +13 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

FOLFIRINOX relative dose intensity and disease control in advanced pancreatic adenocarcinoma

Therapeutic Advances in Medical Oncology, 2021
Background: Most patients with advanced pancreatic adenocarcinoma (PA) treated with FOLFIRINOX experience adverse events requiring dose reduction. We aimed to assess the association between relative dose intensity (RDI) and disease control in a European ...
Antonin Vary, Loïc Lebellec, Frédéric Di Fiore, Nicolas Penel, Claire Cheymol, Emilia Rad, Farid El Hajbi, Astrid Lièvre, Julien Edeline, André Michel Bimbai, Marie-Cécile Le Deley, Anthony Turpin   +11 more
doaj   +1 more source

Simple dynamic electromagnetic radiation detector [PDF]

, 1972
Detector monitors gamma dose rate at particular position in a radiation facility where a mixed neutron-gamma environment exists, thus determining reactor power level changes.
Been, J. F.
core   +1 more source