Results 81 to 90 of about 1,206,776 (294)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Relative dose intensity of systemic chemotherapy in an outpatient cancer center

Acta Medica Academica, 2010
Objective. This study was undertaken to determine the average relative dose intensity (RDI) of chemotherapy administered to patients in a community-based outpatient cancer center. Methods.
Christine Uptigrove, Kari Vavra, Claire Saadeh, Gordan Srkalovic   +3 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Double Machine Learning Approach to Estimate the Effects of Musical Practice on Student's Skills

, 2018
This study investigates the dose-response effects of making music on youth development. Identification is based on the conditional independence assumption and estimation is implemented using a recent double machine learning estimator.
Knaus, Michael C.
core  

The Influence of Exercise Dose, Exercise Intensity, and Weight Loss and Change in C-Reactive Protein in Sedentary Overweight Women [PDF]

, 2012
Objective: To examine the effect physical activity included in a weight loss program has on high sensitivity C-reactive protein (hs-CRP) levels in sedentary overweight women. Design, Setting, and Participants: This study examined the change in hs-CRP
Burke, Lora, Coen, Paul, Henker, Richard, Jakicic, John, Tuite, Patrica K   +4 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Solar-flare shielding with Regolith at a lunar-base site [PDF]

The Langley high energy nucleon transport computer code BRYNTRN is used to predict time-integrated radiation dose levels at the lunar surface due to high proton flux from solar flares.
Nealy, John E., Townsend, Lawrence W., Wilson, John W.   +2 more
core   +1 more source

Algorithm and performance of a clinical IMRT beam-angle optimization system

, 2003
This paper describes the algorithm and examines the performance of an IMRT beam-angle optimization (BAO) system. In this algorithm successive sets of beam angles are selected from a set of predefined directions using a fast simulated annealing (FSA ...
Bortfeld T, Bortfeld T Stein J Preiser K, Braunstein M, Chuang K S, Crooks S M, Das S, David Djajaputra, Geman S, Jackson A, Kirkpatrick S, Llacer J, Mageras G S, Metropolis N, Oldham M, Pugachev A, Pugachev A B, Qiuwen Wu, Radhe Mohan, Rowbottom C G, Rowbottom C G, Rowbottom C G, Spirou S V, Stein J, Webb S, Webb S, Wu Q, Wu Q, Xiang Y, Xing L, Yan Wu   +29 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Drug resistance, supportive care and dose intensity

Annals of Oncology, 1993
Background: Both intrinsic and acquired drug resistance occur in ovarian cancer. Much work on in vivo or in vitro, obtained drug resistance has been done and this knowledge is presently being converted into clinical studies. Materials and methods: The review focuses on the detoxifying system, MDR (multidrug resistance), and supportive care in relation ...
DEVRIES, EGE, HAMILTON, TC, LIND, M, DAUPLAT, J, NEIJT, JP, OZOLS, RF   +5 more
openaire   +2 more sources