Results 131 to 140 of about 1,370,978 (266)

Understanding dopaminergic dose reduction following STN-DBS: mediation analysis. [PDF]

BMJ Neurol Open
Lanore A, Houot M, Basset A, Bendetowicz D, Menon PJ, Bardinet E, Fernandez Vidal S, Cornillault J, Karachi C, Navarro S, Ihle J, Eusebio A, Giordana C, Rouaud T, Drapier S, Guehl D, Marques A, Hubsch C, Jarraya B, Benatru I, Thobois S, Hopes L, Maltete D, Rascol O, Tir M, Moreau C, Tranchant C, Rolland AS, Devos D, Corvol JC, Grabli D, Hainque E, PREDISTIM study group.   +32 more
europepmc   +1 more source

Percentage dose reductions [PDF]

Journal of Prescribing Practice, 2019
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Dose-reduction strategies in whole-body CT for injured patients in the emergency department: a scoping review. [PDF]

Int J Emerg Med
Pereira D, Thevoz F, Rocha AC, Schmidt-Kobbe S, Carron PN, Ageron FX.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Additional Dose Reduction Potential of Vendor-Agnostic Deep Learning Model: A Phantom Study. [PDF]

J Korean Soc Radiol
Kim J, Chang W, Kim JH, Ahn C, Lee H, Cho J, Lee YJ, Kim YH.   +7 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patients' and healthcare providers' views regarding dose reduction of tyrosine kinase inhibitors in chronic myeloid leukemia: a qualitative study. [PDF]

Oncologist
Lokhorst DN, van den Bemt BJF, Smit Y, Hermens RPMG, Blijlevens NMA, Bekker CL.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The regional-control of prophylactic irradiation dose reduction of level Va in nasopharyngeal carcinoma (NPC). [PDF]

Radiat Oncol
Jiang C, Xu C, Zhou D, Kong F, Gao H, Huang X, Feng J, Liu Z, Sun F, Li D.   +9 more
europepmc   +1 more source