Results 131 to 140 of about 72,453 (299)

Laparoscopic Methylene Blue Photodynamic Therapy for Intraabdominal Infection: A Preclinical Feasibility Study in a Rabbit Model of Perforated Appendicitis

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives Perforated appendicitis commonly results in intra‐abdominal infection requiring prolonged antibiotic therapy. Intraoperative antimicrobial adjuncts are limited, and photodynamic therapy (PDT) may provide a targeted, resistance‐independent approach.
Timothy M. Baran, Korry T. Wirth, Matthew M. Byrne, Benjamin Gertsen, Eric Y. Wang, Darrian S. Hawryluk, Martin S. Pavelka, Nicole A. Wilson   +7 more
wiley   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, EarlyView.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp–Logan

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT A customizable, dynamic geometric phantom was developed to bridge the gap between simplistic static phantoms and highly realistic, complex 4D solutions. The phantom enables initial testing, helps detect implementation errors, and supports quantitative evaluation of new dynamic acquisition and reconstruction methods.
Tamás Hakkel, Noémi Kovács, József Sinkó, Domokos Máthé, Krisztián Szigeti   +4 more
wiley   +1 more source

Toxicity of High-Density Polyethylene Nanoparticles in Combination with Silver Nanoparticles to Caco-2 and HT29MTX Cells Growing in 2D or 3D Culture

Molecules
The enormous applications of various nanoparticles (NPs) have raised the possibility that humans may be simultaneously exposed to mixtures of them in real life.
Sylwia Męczyńska-Wielgosz, Katarzyna Sikorska, Malwina Czerwińska, Agnieszka Grzelak, Anna Lankoff, Marcin Kruszewski   +5 more
doaj   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

No evidence of the long-term in vitro toxicity of Aeroxide P25 TiO2 nanoparticles in three mammalian cell lines despite the initial reduction of cellular mitochondrial activity

Nukleonika
We studied the effects of Aeroxide P25 titanium dioxide nanoparticles (TiO2 NPs) with a diameter of 21 nm on induction of DNA damage and long-term survival of three human cell lines: hepatocellular liver carcinoma HepG2, colorectal adenocarcinoma HT29 ...
Męczyńska-Wielgosz Sylwia, Bartłomiejczyk Teresa, Grądzka Iwona, Sommer Sylwester, Węgierek-Ciuk Aneta, Lankoff Anna, Sikorska Katarzyna, Wojewódzka Maria, Dobrzyńska Małgorzata, Kruszewski Marcin   +9 more
doaj   +1 more source

D.RE.A.M.: A software for uncertainties analysis in retrospective dosimetry [PDF]

, 2018
Accidental exposures to ionising radiations are nowadays managed with assistance from biological and physical retrospective dosimetry which are able to provide individual estimates of dose absorbed by victims.
Clemens Woda, Elizabeth Ainsbury, Maurizio Marrale, François Trompier   +3 more
core  

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Radiation Dosimetry Studies for MA-8 (Mercury-Atlas) [PDF]

Radiation Dosimetry Studies for MA-8 (Mercury-Atlas) appearing within Appendix A of unknown publication.
Warren, Carlos, Gill, William
core  

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, EarlyView.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source