Results 41 to 50 of about 359,805 (237)

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola   +5 more
wiley   +1 more source

El vacío del corazón

open access: yesAULA Revista de Humanidades y Ciencias Sociales
Para llegar al cielo, como diría Julio Cortázar, tan solo se requiere una piedrita y la punta de un zapato; y tal es quizá lo necesario para adentrarse en la espesura de la rayuela que es el pensamiento de María Zambrano. Apenas se ha pensado acerca del
Borja López Arranz
doaj   +3 more sources

Form flows function: Learner‐centered game Re‐design in a STEM classroom

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Re‐designing games facilitates interest‐driven learning and immerses learners in systems thinking. However, there are limited studies exploring how the form and function of tabletop games influence learners' design decisions and learning experiences. To address this gap, we conducted a mixed‐methods study in a STEM classroom in western Canada.
Farzan Baradaran Rahimi   +2 more
wiley   +1 more source

Historia de la industria en México, siglos XIX y XX

open access: yesH-Industri@
Presentacion del dossier sobre historia de la industria en Mexico durante los siglo XIX y XX.
Juan Odisio   +1 more
doaj   +1 more source

Making films in a Brazilian slum with children: a participant observation research [PDF]

open access: yes, 2019
This article stands for innovative learning opportunities to social inclusion by film education. The theoretical model is a combined structure coming from approaches and projects of social inclusion through film education.
Juliana, Mirna, Pacheco, Raquel
core   +2 more sources

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

open access: yesBMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam   +4 more
wiley   +1 more source

The transversality of ICTs applied in the pedagogical strategy Integrative training dossier

open access: yesRevista Ingenio, 2015
Higher education institutions must train students to become well-informed and deeply motivated citizens, equipped with a critical sense and capable of analyzing society's problems, seeking solutions for those that arise in society, applying these and ...
Marta Milena Peñaranda Peñaranda
doaj   +1 more source

Informatisation du dossier patient aux Hospices-CHUV et aux Hôpitaux universitaires de Genève : étude comparative [PDF]

open access: yes, 2003
[Table des matières] 1. Introduction 2. Dossier patient, concepts de base: 2.1 Dossier patient: définitions, intérêt et utilisation dans l'environnement hospitalier. 2.2 Dossier patient informatisé: définitions et modèles. 3. Dossier patient aux Hospices-
Zazani, Edlira
core  

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

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