Results 91 to 100 of about 249 (106)

尿酸代謝の種差最小化を指向した動物モデルによる新規尿酸排泄促進薬Dotinuradの薬理学的研究

谷口, 哲也
core  

Discovery of Dotinurad (FYU-981), a New Phenol Derivative With Highly Potent Uric Acid Lowering Activity

ACS Medicinal Chemistry Letters, 2020
Junichiro Uda, Naoki Ashizawa, Takashi Iwanaga   +2 more
exaly   +2 more sources

Changes in Urinary Uric Acid Concentration After Dotinurad Administration to Patients With Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

Clinical Pharmacology in Drug Development
Abstract Dotinurad has been approved in Japan as a selective urate reabsorption inhibitor for the treatment of gout and hyperuricemia. The relationship between uric acid crystallization and the use of uricosuric drugs is widely acknowledged; however, the relationship between changes in urinary uric acid concentration and urine pH or volume has not been
Toshinari Takahashi
exaly   +2 more sources

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Dotinurad: A Novel Selective Urate Reabsorption Inhibitor for the Treatment of Hyperuricemia and Gout

Expert Opinion on Pharmacotherapy, 2021
Tetsuya Taniguchi, Tomohiko Ishikawa, Toshinari Takahashi   +2 more
exaly  

Dotinurad Versus Benzbromarone in Japanese Hyperuricemic Patient With or Without Gout: A Randomized, Double-Blind, Parallel-Group, Phase 3 Study

Clinical and Experimental Nephrology, 2020
Tetsuo Ohashi, Tomomitsu Sasaki, Tatsuo Hosoya   +2 more
exaly  

Ideal Pharmacokinetic Profile of Dotinurad as a Selective Urate Reabsorption Inhibitor

Drug Metabolism and Pharmacokinetics, 2020
Junichiro Uda, Koichi Omura, Tetsuo Ohashi   +2 more
exaly  

A Non-Inferiority Study of the Novel Selective Urate Reabsorption Inhibitor Dotinurad Versus Febuxostat in Hyperuricemic Patients With or Without Gout

Clinical and Experimental Nephrology, 2020
Tatsuo Hosoya
exaly  

A Drug–Drug Interaction Study of a Novel, Selective Urate Reabsorption Inhibitor Dotinurad and the Non-Steroidal Anti-Inflammatory Drug Oxaprozin in Healthy Adult Males

Clinical and Experimental Nephrology, 2020
Yuji Kumagai
exaly  

Comparative Study of a Novel Selective Urate Reabsorption Inhibitor “Dotinurad” Among Patient Groups With Different Stages of Renal Dysfunction

Clinical and Experimental Nephrology, 2021
Toshinari Takahashi, Yuji Hidaka, Tatsuo Hosoya   +2 more
exaly  

Clinical Pharmacological Study of Dotinurad Administered to Male and Female Elderly or Young Subjects

Clinical and Experimental Nephrology, 2020
Tetsuo Ohashi, Tomomitsu Sasaki
exaly