Results 111 to 120 of about 701,417 (304)

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

'Which treatment do you believe you received?' A randomised blinding feasibility trial of spinal manual therapy

Chiropractic & Manual Therapies
Background Blinding is essential for mitigating biases in trials of low back pain (LBP). Our main objectives were to assess the feasibility of blinding: (1) participants randomly allocated to active or placebo spinal manual therapy (SMT), and (2) outcome
Javier Muñoz Laguna, Astrid Kurmann, Léonie Hofstetter, Emanuela Nyantakyi, Julia Braun, Lauren Clack, Heejung Bang, Mazda Farshad, Nadine E. Foster, Milo A. Puhan, Cesar A. Hincapié, the SALuBRITY Blinding Clinician Group   +11 more
doaj   +1 more source

Research progress on the application effect of Montessori method in dementia elderly

Huli yanjiu, 2022
The intervention form and application effect of Montessori method for dementia elderly were reviewed.It was pointed out that most of the current intervention studies on the application of Montessori method in dementia patients were small sample studies ...
LU Xiaohan, SONG Jie, LIU Lin, JIANG Qianqian, CHEN Haiwen, XIAO Ping   +5 more
doaj  

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

A new acupuncture method for management of irritable bowel syndrome: A randomized double blind clinical trial

Journal of Research in Medical Sciences, 2014
Background: Irritable bowel syndrome (IBS) is gastrointestinal functional disorder which is multifactorial with unknown etiology. There are several modalities for treatment of it.
Rahmatollah Rafiei, Mehdi Ataie, Mohammad Arash Ramezani, Ali Etemadi, Behrooz Ataei, Hamidreza Nikyar, Saman Abdoli   +6 more
doaj  

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Is blinding in studies of manual soft tissue mobilisation of the back possible? A feasibility randomised controlled trial with Swiss graduate students

Chiropractic & Manual Therapies
Study design Single-centre, two-parallel group, methodological randomised controlled trial to assess blinding feasibility. Background Trials of manual therapy interventions of the back face methodological challenges regarding blinding feasibility and ...
Javier Muñoz Laguna, Emanuela Nyantakyi, Urmila Bhattacharyya, Kathrin Blum, Matteo Delucchi, Felix Karl-Ludwig Klingebiel, Marco Labarile, Andrea Roggo, Manuel Weber, Thomas Radtke, Milo A Puhan, Cesar A Hincapié   +11 more
doaj   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Femicomfort in the treatment of premenstrual syndromes: a double-blind, randomized and placebo controlled trial.

Iranian Journal of Psychiatry, 2010
Objective: Premenstrual syndromes (PMS) affecting 20-40% of women of reproductive age. The aim of this double blind and placebo controlled trial was to investigate whether femicofort a supplement contains Vitamin B6, Vitamin E and evening primrose oil ...
Ladan Kashani, Nafiseh Saedi, Shahin Akhondzadeh   +2 more
doaj  

Oral urease rapid test serve as an effective complement to the detection of Helicobacter pylori infection through urea breath test

BMC Gastroenterology
The urea breath test (UBT) is the clinic’s most popular and accurate non-invasive diagnostic method for Helicobacter pylori (HP) infection. Yet, it is time-consuming and unavailable to some individuals. The oral rapid urease test (RUT) is an emerging non-
Yaoming He, Chengxing Wang, Wenfeng Luo, Weixing Lin, Shangren Li, Fangmei Xie, Chaorong Zhou, Jian Shen, Weiqiang Zou, Jietao Zhong, Yu Wan, Jinglin Zhao   +11 more
doaj   +1 more source