Abstract Placebo, used here to mean an inert treatment given as if it was a real treatment, means lots of different things to different people. The structure of the article is that it begins by talking about the technical use of placebos in clinical trials, and the extent of the placebo response, then about the mechanism—“How does the ...
H J, McQuay, R A, Moore
openaire +4 more sources
Addressing blinding in classic psychedelic studies with innovative active placebos [PDF]
Jacob S Aday +2 more
exaly +2 more sources
Unethical informed consent caused by overlooking poorly measured nocebo effects [PDF]
Unlike its friendly cousin the placebo effect, the nocebo effect (the effect of expecting a negative outcome) has been almost ignored. Epistemic and ethical confusions related to its existence have gone all but unnoticed.
Howick, Jeremy
core +1 more source
When a placebo is not a ‘placebo’: a placebo effect on postprandial glycaemia [PDF]
What is already known about this subject • Although placebo effects have been shown on subjective continuous variables such as pain, placebo effects on objective continuous variables remain uncertain.• The present, pilot, follow‐up investigation represents the first to assess a placebo effect on the objective continuous measurement of acute ...
John L, Sievenpiper +3 more
openaire +2 more sources
Are Sham Acupuncture Interventions More Effective than (Other) Placebos? A Re-Analysis of Data from the Cochrane Review on Placebo Effects [PDF]
Background and Objective: A recent Cochrane review on placebo interventions for all kinds of conditions found that `physical placebos' (which included sham acupuncture) were associated with larger effects over no-treatment control groups than ...
Linde, Klaus +2 more
core +1 more source
Relieving pain using dose-extending placebos [PDF]
Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be ...
Colloca, Luana +2 more
core +1 more source
Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos [PDF]
BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Adams, Alison E.M. +3 more
core +5 more sources
Strengthening the ethical assessment of placebo-controlled surgical trials : three proposals [PDF]
Peer reviewedPublisher ...
Campbell, Marion K +3 more
core +1 more source
Adjuvant-containing control arms in pivotal quadrivalent human papillomavirus vaccine trials: Restoration of previously unpublished methodology [PDF]
Purpose: Trustworthy reporting of quadrivalent human papillomavirus (HPV) vaccine trials is the foundation for assessing the vaccine's risks and benefits.
Bourgeois, Florence +7 more
core +1 more source

