The use of pure and impure placebo interventions in primary care - a qualitative approach
BMC Family Practice, 2011 Background Placebos play an important role in clinical trials and several surveys have shown that they are also common in daily practice. Previous research focused primarily on the frequency of placebo use in outpatient care.
Senn Oliver +4 more
doaj +1 more source
Placebo Trends across the Border: US versus Canada. [PDF]
PLoS ONE, 2015 Physicians around the world report to using placebos in a variety of situations and with varying degrees of frequency. Inconsistent methodologies, however, complicate interpretation and prevent direct comparisons across studies.
Cory S Harris +2 more
doaj +1 more source
Effects of placebos without deception compared with no treatment: a systematic review and meta-analysis [PDF]
, 2017 Aim Our aim was to address the clinical efficacy of open-label placebos compared with no treatment by systematic review, and meta-analysis where possible.
Roberts, N. +7 more
core +1 more source
Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. [PDF]
PLoS ONE, 2015 Clinical trials use placebos with the assumption that they are inert, thus all placebos are considered to be equal. Here we show that this assumption is wrong and that different placebo procedures are associated to different therapeutic rituals which, in
Fabrizio Benedetti, Sara Dogue
doaj +1 more source
What's in Placebos: Who Knows? Analysis of Randomized, Controlled Trials
, 2010 No regulations govern placebo composition.
Enkin, Murray +5 more
core +1 more source
Placebos: A Psychological and Biological Perspective
, 2023 To gain an understanding of the following: The definition of a placebo effect. The biological and psychological mechanisms of the placebo effect. The importance of placebos in clinical trial design and their ethical considerations.
Prados, J., Gibson, C.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Placebos, Drug Effects, and Study Design: A Clinician's Guide
, 1999 OBJECTIVE: This article examines the role of placebos in evaluating the efficacy of psychiatric drugs. Also addressed are the identification of placebo effects on drugs, the relevance of active placebo, the need for placebo groups in psychotherapy ...
Quitkin, Frederic M.
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Relieving pain using dose-extending placebos [PDF]
, 2016 Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be ...
Colloca, Luana +2 more
core +3 more sources