Results 151 to 160 of about 1,459,434 (319)

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia

AGING MEDICINE, Volume 5, Issue 4, Page 246-256, December 2022., 2022
A 16‐week randomized double‐blind, placebo‐controlled trial for vascular dementia was carried out with WeiNaoKang (or SaiLuoTong). There were significant differences in improvement in cognitive function and activities of daily living, favouring the treatment group.
Junguang Liu, Dennis Chang, Dennis Cordato, Kien Lee, Hugh Dixson, Alan Bensoussan, Daniel Kam Yin Chan   +6 more
wiley   +1 more source

Comparison of Clinical Efficacy of Pipemidic acid (PPA) and Kanamycin (KM) in Bacillary Dysentery by Double Blind Method

, 1983
Makoto Saito, Isao TOMIZAWA, Kazumi KONISHI, Yoshihiko TAKIZAWA, Yoshio MATSUBARA, Takehisa SEO, Hiroko SAGARA, Kazutsugu NIWANO, Yatsuka IMAGAWA, Misako MURATA, Tadao Kondo, Nagayo SHIMIZU, Masachika TSUJI, Gohta MASUDA, Masayoshi Negishi, Hajime Yamagata, Ippei FUJIMORI, Yoshio Kobayashi, Jyuji HOSHINO, Fukiko AMANO, Koji Kato, Tie NAKAMURA, Yoshio Kobayashi, Chihiro Imai, Hiroshi HASHIMOTO, Mitsuru AKAO, Okisuke TSUNODA, Tadakazu AISAKA, Masanobu NIIMI, Yoshikiyo Tanaka, Masayoshi Nakamura, Tooru SUGIHARA, Rintaro Nakaya, Nobuichi Goto, Sankichi Horiuchi, Toshio Chida, Harumi SHIBAOKA, Akiko Shoji, Kiyoshi Hasegawa, Masayuki Ogawa, Hideo Noriki   +40 more
openalex   +2 more sources

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

Advanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang, Peng Qing, Qi Liu, Can Liu, Lei Liu, Xianyang Gan, Kun Fu, Chunmei Lan, Xinqi Zhou, Keith M. Kendrick, Benjamin Becker, Weihua Zhao   +11 more
wiley   +1 more source

Comparative Clinical Study of Roxithromycin and Josamycin for Suppurative Skin and Soft Tissue Infections by a Double-Blind Method

, 1989
Nozomi Nohara, Osamu Akagi, Hiroko Kanzaki, Akiko Kanamoto, Atsunobu Ohara, Akira Ohkawara, Toru Fukaya, Hitoshi Kobayashi, Hidemi Yasuda, Hachiro Tagami, Yoko Kuramoto, Yasumasa ISHIBASHI, Michiro Shimozuma, Ken Iozumi, Hiroyuki YAMAO, Yoshihito IKE, Shôtarô Harada, Kimiko Ogawa, Hiroshi Nakanishi, Shukuka YUN, Atsuyuki IGARASHI, A Kukita, Hiroyuki Ohata, Hirohumi Takahashi, Yasutaka KIMURA, Tatsuya Shimizu, Hisashi Takahashi, Yoshiteru Kawaguchi, Sanae KAWAGUCHI, Kumi Yagi, Jo TODA, Midori Ohta, Yasuo ASADA, Setsuko Nishijima, Shigeo Umemura, Jirô Arata, Hiroyuki TAMAKI, Yasuo Yamamoto, Katsuyuki TAKEDA, Osamu Takahashi, Harukuni Urabe, Tatsuya MIYAOKA, Tatsuyoshi ARAO, Munashi Oishi, Masaaki TASHIRO, Shigeru Nomoto, Nobuya Ogawa, Kōichi Deguchi   +47 more
openalex   +2 more sources

Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas

Advanced Science, EarlyView.
A multi‐functional shear‐thinning hydrogel is engineered to treat enterocutaneous fistulas. This hydrogel can resist external pressures allowing it to remain within the fistula tract and is shown to have significant antimicrobial, pro‐healing, and anti‐inflammatory properties, which were validated in in vitro and in vivo experiments.
Jinjoo Kim, Zefu Zhang, Hassan Albadawi, Hyeongseop Keum, Joseph L. Mayer, Erin H. Graf, Rahmi Oklu   +6 more
wiley   +1 more source

Comparative Test of the Effectiveness of Cefoperazone (T-1551) and Cefazolin (CEZ) on Respiratory Tract Infection by Double Blind Method (II)

, 1980
Keiichi Nakagawa, Kentaro Watanabe, Masaru KOYAMA, Norio Kihara, Tatsuo Suzuki, Akira Fukui, Yasumichi Kato, Akira Saitō, Masumi Tomizawa, Ichiro Nakayama, Yoshio KINOSHITA, Kiyofumi Ishikawa, Fumio Nagahama, Takehito NAKABAYASHI, Shinya YASUDA, Tetsuji KOROKU, Takahisa Saito, Kazunori HARADA, Hiroshi Kon, Takashi Mikami, Nobuo Watanabe, Yasumasa Yokota, T Kirisawa, Akira NAKASATO, Akira Sasaki, Masataka Ito, Ryuji Sato, Kazuo Takebe, Yoshihiro KUMASAKA, Hisashi Nakahata, S Kosaka, Mitsuo Nakamura, Kenichi Imamura, K Machida, Kazuo SASAKI, Katsuhiro OKAMOTO, Shuichiro Yoshida, Hiroyasu Kawabe, Mitsuaki Yoshioka, Shokou NARITA, Masahiro TSUTSUI, Tamotsu Takishima, Sumio Arai, Kazuki Konishi, T Taima, Nobuo Sato, Hajime TAKEDA, Masatoshi NIWAYAMA, Fusanosuke YAMASAKU, Yasutoshi Suzuki, Osamu Sekine, Yoshimaru Usuda, Nobuki Aoki, Yasuko Yuasa, Izumi Hayashi, Masataka Katsu, Mieko KAWAI, T Aoyagi, Noboru Yanai, Iwao Takanami, Masashi Mouri, O Kunii, Kazufuto FUKAYA, Yasushi Ueda, Atsushi Saitô, Jingoro Shimada, Masahisa OOMORI, Kooya SHIBA, Takehisa Yamaji, Hironobu Ihara, Toshio Hōjō, Tadashi Miyahara, Hiroichi Tanimoto, Akio Tachibana, Koichiro NAKADA, M Suzuki, Kaoru Shimada, Takashi Inamatsu, Kyoko URAYAMA, Keimei Mashimo, Sumio YAMAOKA, Junzaburo Kabe, O Kitamoto, Hiroyuki Kobayashi, Hideo IKEMOTO, Ikko WATANABE, Terumi Takahashi, Touji ODAGIRI, Ippei FUJIMORI, Yasuo MASTUOKA, Yoshio Kobayashi, Kojiro Sekita, Kenji Mitsui, Kokichi Fukushima, Akira Ito, Hideyuki Hasegawa, Koichi YAMANAKA, Kunihiko SINDO, Ryuichiro YAMASAKI, Makio KURIHARA   +99 more
openalex   +2 more sources

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source