Results 171 to 180 of about 191,759 (261)

CLINICAL EVALUATION OF DRUG EFTICACY BY THE DOUBLE BLIND METHOD IN MEDICINE

Nihon Naika Gakkai Zasshi, 1976
openaire   +2 more sources

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Effect of evening dexmedetomidine nasal spray on postoperative sleep disturbance in patients undergoing laparoscopic cholecystectomy: protocol for a multicentre, prospective, randomised, double-blind, controlled trial. [PDF]

BMJ Open
Shi W, Zhu S, Xia T, Cui Y, Bo J, Gu X.
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Therapeutic Efficacy of Nanodrug Delivery Compared With Current Nonsurgical Treatments for Patients With Cutaneous Melanoma: A Systematic Review. [PDF]

Cureus
Hussain Z, Buhaimed N, Al Khalifa M, Aljalahma J, Alomran B.   +4 more
europepmc   +1 more source

Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method

Journal of the Japanese Association for Infectious Diseases, 1985
MIKI, Fumio, IKUNO, Yosiyasu, INOUE, Eiji, YOSIYAMA, Minoru, MURATA, Tetsuto, TANIZAWA, Shin-ichi, SAKAMOTO, Kazuo, SAKAI, Hirozumi, SAITO, Akira, TOMIZAWA, Masumi, NAKAYAMA, Ichiro, YAJIMA, Osamu, UJIIE, Akira, TAKEBE, Kazuo, MASUDA, Mitsuo, MURAKAMI, Seiichi, OSONOI, Takeshi, MAEDA, Toshikazu, SASAKI, Kazuo, KONNO, Kiyoshi, OIZUMI, Kotaro, AONUMA, Seiichi, NAGAI, Kosaku, YOSHIDA, Tsukasa, CHIBA, Syuji, SATO, Kazuo, HASUIKE, Teruo, TAMAKI, Shigeru, HAYASHI, Izumi, MIYAHARA, Tadashi, SAITO, Atsushi, IKEMOTO, Hideo, WATANABE, Kazuyoshi, WATANABE, Kentaro, KOYAMA, Masaru, IIJIMA, Fukuo, SHIMADA, Kaoru, INAMATSU, Takashi, URAYAMA, Kyoko, KATSU, Masataka, OGIHARA, Hiroharu, HIGASHI, Fuyuhiko, SEKIMOTO, Toshio, KAWAI, Takeshi, ONAKA, Akio, AJISAWA, Atsushi, KATAYAMA, Tetsuji, MIYAJI, Hayato, MURAYAMA, Yumiko, MASHIMO, Keimei, ITO, Chizuru, TANIMOTO, Hiroichi, YOSHIMURA, Kunihiko, CHONABAYASI, Naohiko, NAKATANI, Tatsuo, KOBAYASHI, Hiroyuki, OSHITANI, Hiroshi, KABE, Junzaburo, ISHIBASHI, Hiroyoshi, SANO, Yasuyuki, FUJIMORI, Ippei, KOBAYASHI, Yoshio, NAKAMURA, Yasushi, OKUBO, Takao, ITO, Akira, MATSUMOTO, Fumio, FUKAYA, Kazufuto, ODAGIRI, Shigeki, IKEDA, Hirotada, NOSE, Keinosuke, MUROHASHI, Kou, WATANABE, Shin-ichiro, TAKEDA, Hajimu, WADA, Koichi, KABASAWA, Tomoko, YAMASAKU, Fusanosuke, SUZUKI, Yasutoshi, SEKINE, Osamu, AOKI, Nobuki, OYAMA, Kaoru, TAKEUCHI, Toshihiko, KATO, Masahito, HANAKI, Hidekazu, USAMI, Ikuji, NAGASAKA, Hirohiko, YAMADA, Yasuo, ITO, Tsuyoshi, TERAO, Naohiko, KUROKI, Hideaki, YAMAMOTO, Toshiyuki, MAEKAWA, Nobuo, NAKANISHI, Michiyasu, NISHIYAMA, Hideki, YAMAMOTO, Takayoshi, SHIBATA, Yasutaku, TSUJINO, Hiroyuki, MIKAMI, Riichiro, SAWAKI, Masayoshi, OKAMOTO, Yuruko, IIDA, Yube, MAEHARA, Keigo, OKUBO, Hiroshi, UEDA, Yoshihiro, TAKAMATSU, Kenji, SOEJIMA, Rinzo, NIKI, Yoshihito, NISHIMOTO, Yukio, KAMITSUNA, Akimitsu, NAKANISHI, Shigekiyo, YAMAKIDO, Michio, HASEGAWA, Kenji, NOUMI, Kazumasa, KURIMURA, Osamu, MASUDA, Tadashi, TSUBURA, Eiro, TAMURA, Masakazu, NAKAYAMA, Tadashi, SENOO, Etsuo, TANI, Kenji, HIGUCHI, Yuji, KAMEI, Toshihiko, SAWAE, Yoshiro, OKADA, Kaoru, HARA, Kohei, SAITO, Atsushi, YAMAGUCHI, Keizo, SUZUYAMA, Yoji, SHIGENO, Yoshiteru, OKUNO, Kazuhiro, OKA, Rokushi, MATSUMOTO, Keizo, MAGATAKE, Tsuyoshi, RIKITOMI, Naoto, HAYASHI, Masato, HOSOYA, Ken-ichi, ZAYASU, Kiyoshi, ARAKI, Yoshiro, ANDO, Masayuki, SUGIMOTO, Mineharu, NAOE, Hiroaki, FUKUDA, Yasutsugu, TOKUNAGA, Katsumasa, SHIMA, Kiyoshi, HIGUCHI, Sadanobu, ITOGA, Takashi, NASU, Masaru, GOTO, Jun, GOTO, Yoichiro, TASHIRO, Takayoshi, KOBARI, Kazumine, NAKATOMI, Masao   +150 more
openaire   +3 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

The Importance of the Gel Immersion Method to Successfully Identify the Jejunojejunal Anastomosis Site After Roux-Y Reconstruction With Double-Balloon Enteroscopy-assisted Endoscopic Retrograde Cholangiopancreatography: A Case Report. [PDF]

DEN Open
Nagano K, Ohnishi K, Ito Y, Hayata N, Okamoto A, Tanimoto T, Suemura S, Hirao M, Hosui A, Hiramatsu N.   +9 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source