[Administration of prostacyclin in sudden deafness. Evaluation with the double blind method].
Prostacyclin (PGI2) connects all the pharmacologic properties of drugs being used till now in sudden deafness. 30 patients with sensori-neural sudden deafness were treated by prostacyclin and placebo in the double-blind test situation. In therapeutic group of 15 patients were 87% of complete recovery, but in placebo only 6%.
E, Olszewski +9 more
openaire +1 more source
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu +6 more
wiley +1 more source
Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) — study design and methods of a randomised controlled double-blinded intervention study [PDF]
Otto Helve +11 more
openalex +1 more source
A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.
K. Gray +7 more
semanticscholar +1 more source
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
A single centre, double arm, triple-blind randomised controlled trial comparing the efficacy of combined letrozole and clomiphene versus the only letrozole as a method of ovulation induction in women with polycystic ovarian syndrome. [PDF]
Soumya Ranjan Panda +3 more
openalex +1 more source
XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan +13 more
wiley +1 more source

