Results 181 to 190 of about 702,312 (347)
Supplementary Materials and Methods from A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of Lovastatin for Various Endpoints of Melanoma Pathobiology
, 2023 Kenneth G. Linden, Sancy A. Leachman, Jonathan S. Zager, James G. Jakowatz, Jaye L. Viner, Christine E. McLaren, Ronald J. Barr, Philip M. Carpenter, Wen‐Pin Chen, Craig A. Elmets, Joseph A. Tangrea, Sung‐Jig Lim, Alistair J. Cochran, Frank L. Meyskens +13 moreopenalex +1 more sourceTargeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui +15 morewiley +1 more sourceInactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension
Advanced Science, EarlyView.Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang +17 morewiley +1 more sourceRedox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy
Advanced Science, EarlyView.This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract
Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However, Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang +13 morewiley +1 more sourceWestern Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease
Advanced Science, EarlyView.In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan +13 morewiley +1 more sourceComparative Clinical Study of T-2588 and Cefaclor for Chronic Respiratory Tract Infections by a Double-Blind Method
, 1986 Hiroyuki Kobayashi, Shin Kawai, Akira Saito, Osamu YAJIMA, Masumi Tomizawa, Ichiro Nakayama, Kiyofumi Ishikawa, Masao Tamura, Takashi Ito, Kenichi Takeuchi, Yoshikatsu NEMOTO, Issei TANIFUJI, Masami Yoshida, Shigeki MORI, Kumi OKABE, Kazutoshi GOMI, Tamotsu Takishima, Shiroh IDA, Isao Ohno, Kiyoshi Konno, Kōtaro Ōizumi, Akira Watanabe, Seiichi Aonuma, Tsugushi ITO, Izumi Hayashi, Masataka Katsu, Mieko KAWAI, Takashi Inamatsu, Kyoko URAYAMA, Shinichi Oka, Makiko Fukayama, Junzaburou KABE, Hiroyoshi ISHIBASHI, Kouichirou KUDOU, Fuyuhiko HIGASHI, Yuzo FUNATSU, Hideo IKEMOTO, Kazuyoshi Watanabe, Hiroichi Tanimoto, Yoshitaka Nakamori, Kunihiko Yoshimura, Tatsuo Nakatani, Naohiko Chonabayashi, Koichiro Nakata, Kyoichi TOZUKA, Kihachiro Shimizu, Atsushi Saitô, Tadashi Miyahara, Keimei Mashimo, Yoshiji YAMANE, Tatsuo Kato, Kaoru Shimada, Shinsaku SAKURAI, Takuo TOYOSHIMA, Kentaro Watanabe, Masaru Koyama, Fukuo IIJIMA, Fumio Matsumoto, Ippei FUJIMORI, Yoshio Kobayashi, Masanori Adachi, Kazufuto FUKAYA, Takeshi Mitsui, Takao Okubo, Akira Ito, Shigeki Odagiri, Masanori MATSUMURA, Kaneo Suzuki, Kou MUROHASHI, Hisako Suzuki, Yasuhiro Yoshiike, Mitsuyo KIUCHI, Tsutomu Fukuda, Masaaki Arakawa, Koichi Wada, Osamu Sekine, Nobuki Aoki, Hajime Takeda, Masanaga TAKATOU, Eishi HIGUCHI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Nobuo Ohya, Mitsuru Hayase, Shunsuke Kitagawa, Kaoru Shimokata, Hiroshi Amano, Saiji Yoshii, Shūzō Sakai, Tatsuo Satake, Kenzoh TAKAGI, Kenichi Yamaki, Toshihiko Takeuchi, Masahito Kato, Joichi Kato, Kunio Nanjo, Riichiro Mikami, Masayoshi Sawaki, Keiichi Mikasa +99 moreopenalex +2 more sourcesDevelopment of Teleoperated Robotic System for Remote Intraocular Microsurgery
Advanced Science, EarlyView.A teleoperated robotic system, characterized by micrometer‐scale precision and a remote center of motion design, is developed and validated to ensure the safety and flexibility of remote intraocular surgery. This system exhibits superior performance in experimental evaluations and holds significant potential for advancing remote microsurgery ...Andi Xu, Zhangkai Lian, Wenben Chen, Yanlin Li, Jiali Liu, Hongli Liang, Rihui Song, Zikai Lin, Mingyuan Li, Yining Huang, Ling Jin, Zheming Zhang, Xiaoyue Wei, Bingqian Liu, Wei Ma, Tao Li, Hang Shao, Wei Liu, Kun Gao, Xin Zhang, Pisong Yan, Ruiyang Li, Ruixin Wang, Xiaohang Wu, Duoru Lin, Xiang Chen, Jinghui Wang, Xingwu Zhong, Mohammad Ali Nasseri, Kai Huang, Haotian Lin +30 morewiley +1 more sourceComparative Clinical Study of Roxithromycin and Josamycin for Suppurative Skin and Soft Tissue Infections by a Double-Blind Method
, 1989 Nozomi Nohara, Osamu Akagi, Hiroko Kanzaki, Akiko Kanamoto, Atsunobu Ohara, Akira Ohkawara, Toru Fukaya, Hitoshi Kobayashi, Hidemi Yasuda, Hachiro Tagami, Yoko Kuramoto, Yasumasa ISHIBASHI, Michiro Shimozuma, Ken Iozumi, Hiroyuki YAMAO, Yoshihito IKE, Shôtarô Harada, Kimiko Ogawa, Hiroshi Nakanishi, Shukuka YUN, Atsuyuki IGARASHI, A Kukita, Hiroyuki Ohata, Hirohumi Takahashi, Yasutaka KIMURA, Tatsuya Shimizu, Hisashi Takahashi, Yoshiteru Kawaguchi, Sanae KAWAGUCHI, Kumi Yagi, Jo TODA, Midori Ohta, Yasuo ASADA, Setsuko Nishijima, Shigeo Umemura, Jirô Arata, Hiroyuki TAMAKI, Yasuo Yamamoto, Katsuyuki TAKEDA, Osamu Takahashi, Harukuni Urabe, Tatsuya MIYAOKA, Tatsuyoshi ARAO, Munashi Oishi, Masaaki TASHIRO, Shigeru Nomoto, Nobuya Ogawa, Kōichi Deguchi +47 moreopenalex +2 more sources
