Results 191 to 200 of about 702,312 (347)

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang   +15 more
wiley   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

open access: yesAdvanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera   +10 more
wiley   +1 more source

Deodorant Effects of Flagyl by Double-Blind Method (on the periodontal Disease)

open access: yesNihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology), 1973
Isao FUJIMAKI   +5 more
openaire   +2 more sources

Chlorpromazine versus placebo for schizophrenia [PDF]

open access: yes, 2014
Abrams   +486 more
core   +1 more source

Artificial Tactile Perception System for Exploring Internal and External Features of Objects via Time‐Frequency Features

open access: yesAdvanced Science, EarlyView.
By engaging in different active exploration behaviors, the tactile perception system can generate distinct signal modes, enabling the application of targeted decoding strategies for efficient and accurate perception of both external and internal object features.
Yuanzhi Zhou   +8 more
wiley   +1 more source

Comparison of Clinical Efficacy of Rokitamycin (RKM) and Ofloxacin (OFLX) for the Treatment of Campylobacter Enteritis by a Double-Blind Method

open access: diamond, 1991
Mitsuo Obana   +60 more
openalex   +2 more sources

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

open access: yesAdvanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou   +9 more
wiley   +1 more source

Comparative Study of TMS-19-Q and Midecamycin for Respiratory Tract Infection by Double-Blind Method

open access: diamond, 1985
Hiroyuki Kobayashi   +99 more
openalex   +2 more sources

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