Results 211 to 220 of about 1,671,076 (389)
Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice
Advanced Science, EarlyView.Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming +22 morewiley +1 more sourceComparative Study of TMS-19-Q and Midecamycin for Respiratory Tract Infection by Double-Blind Method
, 1985 Hiroyuki Kobayashi, Tomoko NIHEI, Hiroaki Takeda, Kohta Kohno, Akira Saito, Masumi Tomizawa, Ichiro Nakayama, Yomei HIRAGA, Koki KIKUCHI, Asako Yamamoto, Kazuo Takebe, Shiro Kosaka, Teruo Nakamura, Shuichiro Yoshida, Masao Tamura, Takashi Ito, Taro CHIBA, Ryoji OGATA, Kazuo TANIFUJI, Kotaro Itakura, Kiyoshi Konno, Kōtaro Ōizumi, Kosaku Nagai, Izumi Hayashi, Tatsuya Abé, Masataka Katsu, Shinji Okui, Masanori Adachi, Atsushi Saitô, Kohya Shiba, Tadashi Miyahara, Tetsuro UGAI, Yoshiji YAMANE, Keimei Mashimo, Keiichi Nakagawa, Masaru Koyama, Ryuji Akiyoshi, Ichiro Murata, Ippei FUJIMORI, Yoshio Kobayashi, Mitsuo Obana, Fumio Matsumoto, Shigeki Odagiri, Hirotada Ikeda, Kaneo Suzuki, Kou MUROHASHI, Tamotsu Kaneko, Osamu Sekine, Yoshimaru Usuda, Nobuki Aoki, Fusanosuke YAMASAKU, Kaoru OYAMA, Toshiyuki Yamamoto, Masahito Kato, Kunio Nanjo, Motoko Yamamoto, Hidekazu Hanaki, Hirohiko Nagasaka, Tsuyoshi Ito, Toshihiko Takeuchi, Masakazu Kohno, Fumio Miki, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzō Soejima, Toshiharu Matsushima, Yoshihito Niki, Hiroshi Kawane, Masayoshi Kawanishi, Chikara Nakahama, Masatoshi Watanabe, Jiro Hino, Michio Yamakido, Yuzo Oda, Osamu Kurimura, Hideo Sasaki, Hirofumi FUKUHARA, Masakazu Tamura, Toshihiro Goto, Eiro Tsubura, Yoshiro Sawae, Kaoru Okada, Yukio Kumagai, Kohei Hara, Atsushi Saitô, Kinichi Izumikawa, Keizo Yamaguchi, Yoji SUZUYAMA, Yoshiteru SHIGENO, Munetaka KOMORI, Naomi Ito, Masao SAI, Hiromaru IWASAKI, Koichi Watanabe, Akira Ikebe, Kozo Yamada, Keizō Matsumoto, Yoshio Uzuka +99 moreopenalex +2 more sourcesSupplementary Materials and Methods from A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of Lovastatin for Various Endpoints of Melanoma Pathobiology
, 2023 Kenneth G. Linden, Sancy A. Leachman, Jonathan S. Zager, James G. Jakowatz, Jaye L. Viner, Christine E. McLaren, Ronald J. Barr, Philip M. Carpenter, Wen‐Pin Chen, Craig A. Elmets, Joseph A. Tangrea, Sung‐Jig Lim, Alistair J. Cochran, Frank L. Meyskens +13 moreopenalex +1 more sourceTroglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial.
Journal of Clinical Endocrinology and Metabolism, 2001 R. Azziz, D. Ehrmann, R. Legro, R. Whitcomb, R. Hanley, A. G. Fereshetian, Mary O’Keefe, M. Ghazzi +7 moresemanticscholar +1 more sourceCuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation
Advanced Science, EarlyView.This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He +12 morewiley +1 more sourcepH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy
Advanced Science, EarlyView.A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei +12 morewiley +1 more source
