Results 211 to 220 of about 702,312 (347)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Sleep disorders in Parkinson's disease: evaluating pharmacological treatments through systematic review and meta-analysis. [PDF]

BMC Neurol
Li J, Zhou R, Deng J, Zhou H, Hu J, Wang X.   +5 more
europepmc   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Effect of probiotics and synbiotics on antimicrobial resistance in frequent infections: a systematic review of clinical trials. [PDF]

Ann Med Surg (Lond)
Mazandarani M, Lashkarbolouk N, Ejtahed HS, Qorbani M.   +3 more
europepmc   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Ketamine treatment alleviates suicide ideation in high-risk populations: a systematic review and meta-analysis. [PDF]

Epidemiol Psychiatr Sci
Tang W, Jiang WW, Que WQ, Zhang WQ, Chen HL, Zhou LJ.   +5 more
europepmc   +1 more source

Co-Relation Between USG- Guided Methods and Conventional Methods for the Assessment of Airway and Cormack Lehane Grading in Adult Patients - A Randomized, Double Blinded Prospective Observational Study

Satish Keshav, Jitendra Kumar, Nidhi Arun, Vishal Verma   +3 more
openalex   +2 more sources

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Efficacy and safety of glucocorticoid-based therapies in the management of keloids: a systematic review and meta-analysis of clinical outcomes. [PDF]

Front Med (Lausanne)
Zhu K, Song Q, Pan L, Xiong F.
europepmc   +1 more source

Supplementary Methods S1 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Robert E. Schoen, Lisa A. Boardman, Marcia Cruz‐Correa, Ajay Bansal, David Kastenberg, Chin Hur, Lynda Dzubinski, Sharon F. Kaufman, Luz M. Rodriguez, Ellen Richmond, Asad Umar, Éva Szabó, Andres Μ. Salazar, John McKolanis, Pamela Beatty, Reetesh K. Pai, Aatur D. Singhi, Camille M. Jacqueline, Riyue Bao, Brenda Diergaarde, Ryan P. McMurray, Carrie Strand, Nathan R. Foster, David M. Zahrieh, Paul J. Limburg, Olivera J. Finn   +25 more
openalex   +1 more source