Results 221 to 230 of about 1,671,076 (389)

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Effects of Urogastrone on Peptic Ulcer Studied with a Double Blind Method

The Journal of Kansai Medical University, 1969
Yoshiko Sameshima, Mineko Sasakawa, Takako Mizuno, Minoru Kamata, Shinichi Nagi   +4 more
openaire   +2 more sources

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Advanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin, Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Christine Jean, Benjamin Fourneaux, Margaux Dore, Lea Fevrier, Ismahane Belhabib, Alexia Brunel, Cindy Neuzillet, Marion Larroque, Carine Joffre, Stephane Rocchi, Nicolas Fraunhoffer, Aurelie Perraud, Muriel Mathonnet, Vera Pancaldi, Laetitia Linares, Juan Iovanna, Nelson Dusetti, Ola Larsson, Remy Nicolle, Stephane Pyronnet, Corinne Bousquet, Yvan Martineau   +25 more
wiley   +1 more source

Allocation Concealment Methods of Alternative Vaccines in Double-blinded Vaccine Plants and Foods Trials

, 2016
Yujia Kong, Jielai Xia, Ling Wang
openalex   +1 more source

Condensation in a closed cavity double skin facade: a model for risk assessment [PDF]

, 2010
Janssens, Arnold, Laverge, Jelle, Schouwenaars, Stijn, Steeman, Marijke, Van Den Bossche, Nathan   +4 more
core   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Preventive effect of liraglutide on postoperative delirium in elderly patients undergoing cardiac surgery: protocol for a single-centre, randomised, double-blind, placebo-controlled trial. [PDF]

BMJ Open
Bai S, Wei M, Wu Y, Zhu X, Wang Z, Wang Y, Zhu C, Guan Y, Wang D, Liu W.   +9 more
europepmc   +1 more source

Comparative Clinical Study of DL-8280 and Cefaclor for Suppurative Skin and Soft Tissue Infections by a Double-Blind Method

, 1984
K Fujita, Mineo NAKANO, E Nonami, Takako Shishiba, Michio Katsumata, Naoshige Horie, Ryoji Watanabe, A Kukita, Shinichi Watanabe, Toru Someya, M Shimotsuma, Masutaka Furue, Mitsuru Iwata, Hisashi Takahashi, Masanori Takeshima, Yusho Miura, Hitoshi Kobayashi, Chikako Nohira, T. Onozuka, Masatoshi ITO, Kumiko HOSONO, Takanori TOMIZAWA, Junko YAMAGUCHI, Miwako KINOSHITA, Mitsuyoshi HONDA, Motoyasu SATO, Masako KUSUNOKI, Michi FUJIOKA, Munekazu NISHIWAKI, Haruko HINO, Takuya KITAJIMA, Takashi Anzai, Shozo Sato, Kumiko Jitsukawa, S Sasagawa, Michihito Niimura, Takayuki TOZAWA, Kazuo TSUJI, Yasuo ASADA, Hideo Hishikawa, Nozomi Nohara, Shigeo Umemura, Jirô Arata, Yasuo Yamamoto, Harukuni Urabe, Yasuki NII, Kyoko Jinnai, Nobuya Ogawa   +47 more
openalex   +2 more sources

Guilty at First Sight: Legislation to Prevent the Misidentification of Innocent Persons in Illinois [PDF]

, 2019
Murphy, Kaitlyn A.
core   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source