Results 61 to 70 of about 334,970 (312)

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial [PDF]

, 2012
Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality ...
Crugel Monica, Fox, C, Fox Chris, Treloar Adrian, Ballard, C, Treloar, A, Maidment Ian, Livingston, G, Boustani Malaz, Ian Maidment, Boustani, M, Malaz Boustani, Maidment, Ian D., Livingston Gill, Auestad Bjorn Henrik, Gill Livingston (167081), Fox, Chris, Treloar, Adrian, Auestad, Bjorn Henrik, Bjorn Henrik Auestad, Ian Maidment (167066), Auestad, BH, Katona, C, Maidment, Ian, Coulton, Simon, Clive Ballard (89605), Coulton, S, Ballard, Clive G., Maidment, I, Cornelius Katona, Coulton Simon, Simon Coulton (167071), Ballard Clive, Boustani, Malaz, Livingston, Gill, Chris Fox (167059), Auestad, Bjorn H., Monica Crugel, Adrian Treloar, Katona Cornelius, Bjorn Henrik Auestad (167069), Adrian Treloar (167073), Katona, Cornelius, Gill Livingston, Simon Coulton, Cornelius Katona (15210), Clive Ballard, Ballard, Clive, Crugel, Monica, Monica Crugel (167063), Malaz Boustani (167077), Chris Fox, Crugel, M, Fox, Christopher   +53 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Challenges and Opportunities: A Phenomenological Analysis of Blind Passengers' Train Travel Experiences in Indonesia

Jurnal Entrepreneur dan Entrepreneurship
This research aims at the experiences of blind passengers using long-distance intercity trains. Although prior research has been done on transportation use by blind consumers, their customer experience in Indonesia has yet to be thoroughly examined ...
Hendyansyah Putra, Innocentius Bernarto, Rudy Pramono   +2 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep)

BMC Research Notes, 2019
Objective To examine whether vitamin D supplementation in patients with depression would result in a reduction in Hamilton D-17 depression score (primary outcome) at 3 and 6 months compared to controls and to explore the correlations between serum ...
Jens Peter Hansen, Manan Pareek, Allan Hvolby, Anne Schmedes, Tomas Toft, Erik Dahl, Connie Thurøe Nielsen   +6 more
doaj   +1 more source

Blind adaptive equalizer for broadband MIMO time reversal STBC based on PDF fitting [PDF]

, 2009
In this paper, we propose a new blind adaptive technique used for the equalisation of space-time block coded (STBC) signals transmitted over a dispersive MIMO channel.
Bendoukha, S., Stephan Weiss, Samir Bendoukha, Weiss, S., Daas, A., Adel Daas   +5 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source