Results 51 to 60 of about 12,798 (256)
MathematicsPurpose—This study aims to perform an in-depth analysis of double-diffusive natural convection (DDNC) in an irregularly shaped porous cavity. We investigate the convective heat transfer process induced by the lower wall treated as a heat source while the
Imran Shabir Chuhan +5 more
doaj +1 more source
Journal of Mathematics, 2021 This study presents numerical simulations on double-diffusive flow of a nanofluid in two cavities connected with four vertical gates. Novel shape of an outer square shape mounted on a square cavity by four gates was used.
Abdelraheem M. Aly +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
, 2013 + ID der Publikation: hslu_60973 + Art des Beitrages: Dissertation + Name der Universität / Institution inkl. Ort: ETH Zürich + Land der Universität / Institution: Schweiz + Sprache: Deutsch + Letzte Aktualisierung: 2019-07-02 13:22 ...
openaire +3 more sources
Distribution, Mixing, and Transformation of a Loop Current Ring Waters: The Case of Gulf of Mexico
Geophysical Research LettersMesoscale warm‐core rings, known as Loop Current rings (LCRs) reshape the Gulf of Mexico water masses by redistributing large amounts of heat and salt laterally.
Mathieu Gentil +8 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source