Results 61 to 70 of about 18,661 (284)

Thermohaline mixing and the photospheric composition of low-mass giant stars [PDF]

, 2011
We compute full evolutionary sequences of red giant branch stars close to the luminosity bump by including state of the art composition transport prescriptions for the thermohaline mixing regimes. In particular we adopt a self-consistent double-diffusive
Althaus, Cantiello, Charbonnel, Charbonnel, Charbonnel, Charbonnel, Charbonnel, Denissenkov, Denissenkov, Denissenkov, Eggleton, F. C. Wachlin, Geisler, Gilroy, Gilroy, Gratton, Grossman, Grossman, Iben, Kippenhahn, Krishnamurti, L. G. Althaus, Luck, M. M. Miller Bertolami, Merryfield, Recio-Blanco, Shetrone, Smiljanic, Smith, Spite, Stancliffe, Traxler, Ulrich, Weaver   +33 more
core   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Double-diffusive magnetoconvection in a tilted porous parallelogrammic domain with discrete heated-cooled segments: Leveraging machine learning and CFD approach

Results in Engineering
Buoyancy-driven convection resulting from the combined buoyancy is commonly observed in various engineering applications, particularly for equipment located within confined enclosures.
P. Ravindra, M. Sankar, Suresh Rasappan, Wardah Abdullah Al Majrafi, Pugalarasu Rajan, S. Sanal Kumar   +5 more
doaj   +1 more source

Double-diffusive instability in core-annular pipe flow [PDF]

, 2016
The instability in a pressure-driven core-annular flow of two miscible fluids having the same densities, but different viscosities, in the presence of two scalars diffusing at different rates (double-diffusive effect) is investigated via linear stability
Sahu, Kirti Chandra
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dynamics of fingering convection II: The formation of thermohaline staircases [PDF]

, 2010
Regions of the ocean's thermocline unstable to salt fingering are often observed to host thermohaline staircases, stacks of deep well-mixed convective layers separated by thin stably-stratified interfaces.
A. TRAXLER, Huppert, N. BRUMMELL, P. GARAUD, S. STELLMACH, Stern, Stern, T. RADKO   +7 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Two-Scalar Turbulent Rayleigh-Benard Convection: Numerical Simulations and Unifying Theory [PDF]

, 2017
We conduct direct numerical simulations for turbulent Rayleigh-B\'{e}nard (RB) convection, driven simultaneously by two scalar components (say, temperature and salt concentration) with different molecular diffusivities, and measure the respective fluxes ...
Lohse, Detlef, Verzicco, Roberto, Yang, Yantao   +2 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source