Results 91 to 100 of about 2,247,060 (230)

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

Double aortic arch [PDF]

European Heart Journal, 2012
Andreas M E, Koch, Martin, Glöckler, Robert, Cesnjevar   +2 more
openaire   +2 more sources

Crossed pulmonary arteries with double aortic arch: a rare association

, 2014
Crossed pulmonary arteries is a rare, benign congenital anomaly. Both pulmonary arteries cross each other on their course to each respective lung, thus forming a crisscross pattern.
Alhallaq, Mahmoud Omar, Zaqout, Mahmoud, De Wolf, Daniël, Mahmoud Zaqout   +3 more
core   +1 more source

Standardized Reporting of Cardiac Magnetic Resonance Examinations in Children With Cardiac Diseases and Adults With Congenital Heart Disease: A Scientific Statement From the Association for European Pediatric and Congenital Cardiology (AEPC) and the International Society for Magnetic Resonance in Medicine (ISMRM)

Journal of Magnetic Resonance Imaging, EarlyView.
Francesca Raimondi, Inga Voges, Lamia Ait‐Ali, Sonya Babu‐Narayan, Rene Botnar, Barbara Burkhardt, Adrienne Campbell‐Washburn, Dominik Daniel Gabbert, Georg Hansmann, Willem A. Helbing, Hasan Hosan, Sylvia Krupickova, Heiner Latus, Duarte Martins, Colin McMahon, Christian Meierhofer, Vivek Muthurangu, Tiina Ojala, Pim van Ooij, Claudia Prieto, Milan Prsa, Kuberan Pushparajah, José F. Rodríguez Palomares, Samir Sarikouch, Lars Grosse‐Wortman, F. Gerald Greil, Heynric Grotenhuis   +26 more
wiley   +1 more source

Expanding the Phenotypic Spectrum of FTO‐Related Developmental Disorder Caused by Biallelic Variants in FTO

Clinical Genetics, EarlyView.
We report 13 additional individuals from nine families, evaluating in detail the genotypic and phenotypic spectrum in comparison with the previously reported individuals. Our work substantially broadens the phenotypic spectrum, ranging from the severe and lethal to a milder developmental phenotype.
Radhakrishnan Periyasamy, Gopika Kanippayyur Narayanan, Dhanya Lakshmi Narayanan, Nisha Mohan, Sheela Nampoothiri, Dhanya Yesodharan, Mathilde Nizon, Leïla Ghesh, Meenakshi Bhat, Monisha Morris, Sarah Ghazali, Mahmoud Almutadares, Deema Aljeaid, Shahyan Siddiqui, Anju Shukla, Isabel Filges   +15 more
wiley   +1 more source

Balanced double aortic arch with tetralogy of Fallot

, 2014
We present a rare case of balanced double aortic arch in a 19year old cyanotic boy, a known case of tetralogy of Fallot. This was suspected on chest X-ray and confirmed on further imaging by cardiac catheterization and computed tomography. We discuss the
Girish Meenahalli Palleda, Sumod Kurien, Mohit D. Gupta, Bhagya Narayan Pandit, Sanjay Tyagi   +4 more
core   +1 more source

Cerebral Ventriculomegaly With Abnormality of the Aqueduct of Sylvius: A Case Series

Clinical Genetics, EarlyView.
Genetic testing leads to a diagnostic rate of ~30% in a fetal cohort with cerebral ventriculomegaly where the neuropathological examination revealed a stenosis or atresia of the aqueduct of Sylvius. ABSTRACT Fetal cerebral ventriculomegalies are brain anomalies with potentially poor neurodevelopmental prognosis.
Romain Nicolle, Laurence Loeuillet, Bettina Bessieres, Lucile Boutaud, Sarah Grotto, Nicolas Bourgon, Maryse Bonniere, Jelena Martinovic, Aude Tessier, Nathalie Roux, Giulia Petrilli, Naima Talhi, Marion Lesieur‐Sebellin, Jérémy Bertrand, Anaïs L'haridon, Aurélie Coussement, Marie‐Laure Maurin, Marie‐Paule Beaujard, Valérie Malan, Férechté Razavi, Tania Attie‐Bitach   +20 more
wiley   +1 more source

Diagnosis and surgical repair of congenital double aortic arch in infants

Journal of Cardiothoracic Surgery, 2019
Objectives Double aortic arch (DAA) is a rare congenital vascular malformation. This study aims to summarize the experience of diagnosis and surgical treatment for congenital double aortic arch.
Yiting Yang, Xin Jin, Zhengxia Pan, Yonggang Li, Chun Wu   +4 more
doaj   +1 more source

Sclerostin regulates bone morphogenetic protein (BMP) bioavailability through interactions with BMP complexes and fibrillin microfibrils

The FEBS Journal, EarlyView.
Sclerostin (SOST) is a multifunctional extracellular modulator of BMP and Wnt signaling. SOST binds with high affinity to fibrillin‐1 and fibrillin‐2, localizing it to fibrillin microfibrils and regulating its extracellular bioavailability. Fibrillin‐bound SOST cannot engage BMP‐7 prodomain (PD) complexes, revealing a competitive mechanism that ...
Annkatrin Correns, Fady Marcous, Steffen Lütke, Matthias Mörgelin, Philipp Barnowski, Ariane G. Furlan, Nathalie H. Schröder, Bodo Levkau, Sarah Riek, Martin Mollenhauer, Manuel Koch, Gerhard Sengle   +11 more
wiley   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source