Results 91 to 100 of about 1,233,954 (328)
Trials, 2012 Background Maintenance of the blind-to-treatment allocation is one of the most important means of avoiding bias in randomised controlled clinical trials.
Wright Stephen +2 more
doaj +1 more source
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Integration of Bioengineered Tools in Assisted Reproductive Technologies
Advanced Healthcare Materials, EarlyView.A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak +3 more
wiley +1 more source
They Come to Play: Supply Effects in an Economic Experiment [PDF]
Our experiment challenges the standard, social preference, interpretation of choices in the double blind dictator game. In our bilateral treatment both groups are endowed with $20, any fraction of which can be passed to a randomly determined player in ...
Allison Liati +2 more
core
Azathioprine in active chronic iridocyclitis. A double-blind controlled trial. [PDF]
, 1969 John D. Mathews +3 more
openalex +1 more source
Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery
Advanced Healthcare Materials, EarlyView.This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis +6 more
wiley +1 more source
Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Advanced Healthcare Materials, EarlyView.This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani +4 more
wiley +1 more source
Педиатрическая фармакология, 2018 What can become the basis for the decision making when prescribing a medicine, choosing one instead of another? Words and their combinations ‘randomised controlled study’, ‘double blind’, ‘meta-analysis’, ‘relevant difference’ have a kind of hypnotic ...
Yuliya A. Petrovskaya +2 more
doaj +1 more source
Topical ampicillin in the appendicectomy wound: Report of double-blind trial [PDF]
, 1969 J W S Rickett, B. T. Jackson
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Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis
Advanced Healthcare Materials, EarlyView.An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back +3 more
wiley +1 more source