Results 61 to 70 of about 86,778 (284)
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Intricacies of coupled molecular diffusion on double diffusive viscoelastic porous convection
The effect of cross-diffusion on the onset of convective instability in a horizontal porous layer saturated with double diffusive viscoelastic fluid is investigated.
I.S. Shivakumara +2 more
doaj +1 more source
A blue sky catastrophe in double-diffusive convection
A global bifurcation of the blue sky catastrophe type has been found in a small Prandtl number binary mixture contained in a laterally heated cavity. The system has been studied numerically applying the tools of bifurcation theory.
E. Knobloch +9 more
core +1 more source
Simulations of stellar convection, pulsation and semiconvection [PDF]
We report on modelling in stellar astrophysics with the ANTARES code. First, we describe properties of turbulence in solar granulation as seen in high-resolution calculations.
Bascoul +13 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Distribution, Mixing, and Transformation of a Loop Current Ring Waters: The Case of Gulf of Mexico
Mesoscale warm‐core rings, known as Loop Current rings (LCRs) reshape the Gulf of Mexico water masses by redistributing large amounts of heat and salt laterally.
Mathieu Gentil +8 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Purpose—This study aims to perform an in-depth analysis of double-diffusive natural convection (DDNC) in an irregularly shaped porous cavity. We investigate the convective heat transfer process induced by the lower wall treated as a heat source while the
Imran Shabir Chuhan +5 more
doaj +1 more source

