Results 111 to 120 of about 2,208,881 (288)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Formés et formateurs face à la 'double contrainte' des programmes de formation à l'employabilité des chômeurs de longue durée [PDF]
Cet article présente une recherche de terrain menée dans trois pays européens (Belgique, France et Royaume-Uni) sur la formation des chômeurs de longue durée.
Darmon, Isabelle +3 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Study on Stability of Small Clearance Shield Tunnel Excavation Face
Chengshi guidao jiaotong yanjiu［Objective］ Determine the limit support pressure required to maintain tunnel face stability during the construction of double-line small clearance shield tunnel. ［Method］ The excavation stability of double-line small clearance shield tunnel is studied by
GAO Qi
doaj +1 more source
Widespread outbreak of the COVID-19 virus during the second wave pandemic: the double face of absolute numbers. [PDF]
Pathog Glob Health, 2021 Zuin M +3 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Geometric Design and Basic Feature Analysis of Double Helical Face Gears
MachinesThis study aims to address the problem that traditional helical gears generate significant axial forces during transmission and innovatively proposes a design scheme of double helical face gears (DHFG). An accurate mathematical model of the tooth surface
Xiaomeng Chu, Faqiang Chen
doaj +1 more source