Results 141 to 150 of about 1,857 (290)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Ten years on: a 'Montgomery map' for healthcare professionals in the United Kingdom and Beyond. [PDF]

Med Law Rev
Mulheron RP.
europepmc   +1 more source

Double Materiality in Corporate Sustainability: Insights from Italian Companies

This chapter explores the double materiality assessment process, which is a key aspect of sustainability reporting. Through a comparative analysis of three Italian companies that voluntarily undertake the double materiality assessment (DMA), the study ...
Bernini, Francesca, Leto, Lorenzo, Vito, Diletta, D'Onza, Giuseppe   +3 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multimodal interaction enhancement of digital cultural heritage system: user behavior analysis and interface reconstruction of the heritage scanning library of the palace museum. [PDF]

Sci Rep
Ke L, Qin H, Long J, Xiao P.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Do ESG Frameworks Capture Corporate Health Impacts? An Analysis of the Food and Beverage Industry. [PDF]

Int J Environ Res Public Health
Burgess R, Chen K, Kim SJ, Dharia N, Lin C, Srebotnjak T, Grierson L, Freudenberg N, Esty DC, Ransome Y.   +9 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A double-edged sword: materiality classifications of sustainability topics. [PDF]

Rev Acc Stud
Göttsche M, Griffin PA, Habermann F, Schiemann F, Spandel T.   +4 more
europepmc   +1 more source

Corporate sustainability reporting: external audit of the double materiality principle in the Latvian banking sector

Maģistra darba tēma ir “Korporatīvās ilgtspējas ziņošana: dubultā būtiskuma principa ārējā revīzija Latvijas banku sektorā”. Darba mērķis ir identificēt banku sektora ilgtspējas ziņojumu, tai skaitā dubultā būtiskuma principa, pārbaudes trūkumus un ...
Degole, Dace
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