Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effect Mechanism of Extracurricular Tuition and Implications on "Double Reduction" Policy: Extracurricular Tuition Intensity, Psychological Resilience, and Academic Performance. [PDF]
Behav Sci (Basel), 2023 Fu C, Ou H, Mo T, Liao L.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Parents' Educational Anxiety Under the "Double Reduction" Policy Based on the Family and Students' Personal Factors. [PDF]
Psychol Res Behav Manag, 2022 Chen G, Oubibi M, Liang A, Zhou Y.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Exploration of Sports Participation and Curriculum Resource Utilization in Primary Schools Before and After the "Double Reduction". [PDF]
Front Psychol, 2022 Liu S, Wang G.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Reduction formula of a double binomial sum
TURKISH JOURNAL OF MATHEMATICS, 2018 Summary: A class of double sums with binomial coefficients are evaluated by combining finite differences with partial fraction decompositions.
openaire +2 more sources
Research on the New Ecological Model under the Environment of "Double Reduction" of Children's Community Education Services. [PDF]
J Environ Public Health, 2022 Zhou J.
europepmc +1 more source