Results 81 to 90 of about 1,100,143 (252)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

School Governance Capacity in the Implementation of "Double Reduction" Policy

Jiaoshi jiaoyu xuebao
The school governance capacity in the implementation of the "Double Reduction" Policy is directly related to the alleviation of students' academic burden and the reconstruction of a good basic education ecology.
ZHANG Xue
doaj   +1 more source

DOUBLE REDUCTION IN AUTOTETRAPLOID MAIZE [PDF]

Genetics, 1966
C S, Levings, D E, Alexander
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Application of the generalized double reduction method to the (1+1)-dimensional Kaup–Boussinesq (K–B) system: Exploiting Lie symmetries and conservation laws

Partial Differential Equations in Applied Mathematics
This paper explores the application of the generalized double reduction method to the (1+1)-dimensional Kaup–Boussinesq system, which models nonlinear wave propagation.
Molahlehi Charles Kakuli
doaj   +1 more source

Pairwise-Distance-Analysis-Driven Dimensionality Reduction Model with Double Mappings for Hyperspectral Image Visualization

Remote Sensing, 2015
This paper describes a novel strategy for the visualization of hyperspectral imagery based on the analysis of image pixel pairwise distances. The goal of this approach is to generate a final color image with excellent interpretability and high contrast ...
Yi Long, Heng-Chao Li, Turgay Celik, Nathan Longbotham, William J. Emery   +4 more
doaj   +1 more source

Doubling Down on Emissions Reductions

Philosophy & Technology
Abstract Especially in the public discourse, there seems to be a tendency to focus not on mitigation, but on the supplementary interventions – adaptation, negative emissions technologies, and solar radiation management – to tackle climate change.
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source