Results 111 to 120 of about 3,352,430 (254)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Break a Leg

open access: yes, 2015
A 95-minute stand-up comedy show written and performed by Oliver Double. Venue: The Gulbenkian Theatre, Canterbury Date: Sunday, 6th December 2015 Audience: 176 Description: A show about the recovery process following a broken femur, exploring ...
Double, Oliver
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Generalized Fermat, Double Fermat and Newton Sequences

open access: yes, 2013
[[abstract]]In this paper, we discuss the relationship among the generalized Fermat, double Fermat, and Newton sequences. In particular, we show that every double Fermat sequence is a generalized Fermat sequence, and the set of generalized Fermat ...
Du, Bau-Sen; Huang, Sen-Shan; Li, Ming-Chia
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Some generalized difference double sequence spaces defined by a sequence of Orlicz-functions

open access: yesCubo, 2012
In the present paper we introduce some generalized difference double sequence spaces defined by a sequence of Orlicz-functions. We study some topological properties and some inclusion relations between these spaces.
Kuldip Raj, Sunil K Sharma
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

On some double lacunary strong Zweier convergent sequence spaces

open access: yes, 2013
In this paper we define three classes of new double sequence spaces. We give some relations related to these sequence spaces. We also introduce the concept of double lacunary statistical Zweier convergence and obtain some inclusion relations related to ...
Esi, Ayhan, Acikgoz, Mehmet
core  

On the Double Sequence Space Hϑ as an Extension of Hahn Space h

open access: yesInternational Journal of Mathematics and Mathematical Sciences
Double sequence spaces have become a significant area of research within functional analysis due to their applications in various branches of mathematics and mathematical physics.
Orhan Tuǧ   +3 more
doaj   +1 more source

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