Results 121 to 130 of about 3,352,430 (254)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
(Aσ)Δ -double sequence spaces via Orlicz functions and double statistical convergence [PDF]
, 2007 The aim of this paper is to introduce and study a new concept of strong double (A?)? -convergence sequences with respect to an Orlicz function, and some properties of the resulting sequence spaces were also examined.
Patterson, Richard F., Savaş, Ekrem
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
On Generalized Orlicz Sequence Spaces Defined by Double Sequences
Fasciculi Mathematici, 2015 Abstract S.D. Parashar and B. Choudhary defined in 1994 certain paranorms for some Orlicz sequence spaces. Their ideas are applied later for topologization of various generalized Orlicz sequence spaces. The author determines in 2011 some alternative F-seminorms (which are also paranorms) for such spaces. In this paper these results are extended to
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Double Sequences and Double Series
, 2006 This research considers two traditional important questions, which are interesting, at least to most mathematicians. The first question arises in the theory of double sequences of complex numbers, which concerns the relationship, if any, between the following three limits of a double sequence s : N×N ...
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Asymptotic equivalence of double sequences
, 2012 The goal of this paper is to present a four-dimensional matrix characterization of asymptotic equivalence of double sequences. This will be accomplished with the following notion of asymptotic equivalence of double sequences. Two double sequences are asymptotic equivalent if and only if P − limk,l xk,l yk,l = 1, where x and y are selected judicially ...
Patterson, Richard F., Savas, Ekrem
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
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Master's Recital: David Malone, double bass
, 2008 This recial is given in partial fulfillment of the requirements for the Master of Music degreeMr. Malone is a student of Paul Ellison.Sonata in D Major, BWV 1028, Johann Sebastian Bach (1685-1750) -- Concertino for flute, viola, and double bass (1925 ...
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