Results 51 to 60 of about 3,352,430 (254)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Webbed spaces, double sequences, and the Macke convergence condition

International Journal of Mathematics and Mathematical Sciences, 1999
In [3], Gilsdorf proved, for locally convex spaces, that every sequentially webbed space satisfies the Mackey convergence condition. In the more general frame of topological vector spaces, this theorem and its inverse are studied. The techniques used are
Armando García-Martínez
doaj   +1 more source

Quasi-Norms for a Double Sequence

Interdisciplinary Information Sciences, 2002
Summary: The purpose of this note is to define and characterize different kinds of quasi-norms for a double sequence obtained by generalizing the \(l^p\)-norm. In particular, we focus on two weak \(l^p\)-norms: successive weak \(l^p\)-norm and standard weak \(l^p\)-norm. We give upper and lower bounds of the ratio of a successive weak \(l^p\)-norm to a
UENO, Toshihide, TOKUYAMA, Takeshi, OKADA, Masami   +2 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Laughing all the way to the bank? Alternative comedy in the provinces

, 1994
Metropolitan snobbery and the logistics of scale both militate against the success of comedians working in the regions. Yet, as Oliver Double here argues, the scene has been a lively one, often daring in its style and range alike – at least until the ...
Double, Oliver
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Characterization in stand-up comedy: From Ted Ray to Billy Connolly, via Bertolt Brecht [PDF]

, 2000
Stand-up comedy is often distinguished from straight acting by its apparent lack of characterization-the comedian appearing onstage apparently as him or herself.
Double, Oliver
core   +1 more source

Multistage axial hydro-forging sequence of double-stepped tube with large expansion ratio

International Journal of Lightweight Materials and Manufacture, 2020
In order to manufacture the double-stepped tube with large expansion ratio, a multistage axial hydro-forging sequence was proposed by combination of hydroforming with movable dies in this paper. The new forming process is divided into four stages. In the
Lei Sun, Caiyuan Lin, Guodong Wang, Guannan Chu   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source