Results 51 to 60 of about 213,326 (261)
Efficient generation of conditional knockout mice via sequential introduction of lox sites
Scientific Reports, 2017 Conditional knockout using Cre/lox is essential for functional analysis of genes. CRISPR/Cas in combination with two sets of guide RNAs and a single-stranded oligonucleotide enables simultaneous insertion of two lox sequences.
Takuro Horii +5 more
doaj +1 more source
Frontiers in Medicine, 2023 Ocular cyclotorsion is treatable only with surgery. The surgical procedure must be tailored individually to the specific etiologies causing the horizontal and vertical strabismus and its torsional components. An adjustable surgical approach is often used
Lung-Chi Lee +4 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Spherical Steiner Symmetrizations
AxiomsIn this paper, we primarily investigate and establish several properties of spherical Steiner symmetrizations, along with the isoperimetric property of the spherical cap in Sn.
Youjiang Lin, Zhilang Deng
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
New Constructions of One-Coincidence Sequence Sets over Integer Rings
MathematicsIn this paper, we introduce new constructions of one-coincidence frequency-hopping sequence (OC-FHS) sets over integer rings. These OC-FHSs are designed to minimize interference in frequency-hopping multiple access (FHMA) systems, which are widely used ...
Jin-Ho Chung, Daehan Ahn, Daehwan Kim
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA
Frontiers in Oncology, 2019 Small double-stranded RNAs with certain sequence motifs are able to interact with pattern-recognition receptors and activate the innate immune system.
Mikhail I. Zharkov +3 more
doaj +1 more source
Axioms, 2020 We call a subset M of an algebra of sets A a Grothendieck set for the Banach space b a ( A ) of bounded finitely additive scalar-valued measures on A equipped with the variation norm if each sequence μ n n = 1 ...
Juan Carlos Ferrando +2 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source