Results 71 to 80 of about 965,807 (276)
New Constructions of One-Coincidence Sequence Sets over Integer Rings
MathematicsIn this paper, we introduce new constructions of one-coincidence frequency-hopping sequence (OC-FHS) sets over integer rings. These OC-FHSs are designed to minimize interference in frequency-hopping multiple access (FHMA) systems, which are widely used ...
Jin-Ho Chung, Daehan Ahn, Daehwan Kim
doaj +1 more source
On the computation of zone and double zone diagrams
, 2017 Classical objects in computational geometry are defined by explicit relations. Several years ago the pioneering works of T. Asano, J. Matousek and T. Tokuyama introduced "implicit computational geometry", in which the geometric objects are defined by ...
A Granas +30 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA
Frontiers in Oncology, 2019 Small double-stranded RNAs with certain sequence motifs are able to interact with pattern-recognition receptors and activate the innate immune system.
Mikhail I. Zharkov +3 more
doaj +1 more source
Axioms, 2020 We call a subset M of an algebra of sets A a Grothendieck set for the Banach space b a ( A ) of bounded finitely additive scalar-valued measures on A equipped with the variation norm if each sequence μ n n = 1 ...
Juan Carlos Ferrando +2 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Reidemeister/Roseman-type Moves to Embedded Foams in 4-dimensional Space [PDF]
, 2012 The dual to a tetrahedron consists of a single vertex at which four edges and six faces are incident. Along each edge, three faces converge. A 2-foam is a compact topological space such that each point has a neighborhood homeomorphic to a neighborhood of
Carter, J. Scott
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source