Results 51 to 60 of about 218,680 (262)

Wijsman statistical convergence of double sequences of sets

, 2020
Summary: In this paper, we study the concepts of Wijsman statistical convergence, Hausdorff statistical convergence and Wijsman statistical Cauchy double sequences of sets and investigate the relationship between them.
Nuray, Fatih, Ulusu, Uğur, Dündar, Erdinç   +2 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Learning epistatic gene interactions from perturbation screens.

PLoS ONE, 2021
The treatment of complex diseases often relies on combinatorial therapy, a strategy where drugs are used to target multiple genes simultaneously. Promising candidate genes for combinatorial perturbation often constitute epistatic genes, i.e., genes which
Kieran Elmes, Fabian Schmich, Ewa Szczurek, Jeremy Jenkins, Niko Beerenwinkel, Alex Gavryushkin   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Efficient generation of conditional knockout mice via sequential introduction of lox sites

Scientific Reports, 2017
Conditional knockout using Cre/lox is essential for functional analysis of genes. CRISPR/Cas in combination with two sets of guide RNAs and a single-stranded oligonucleotide enables simultaneous insertion of two lox sequences.
Takuro Horii, Sumiyo Morita, Mika Kimura, Naomi Terawaki, Mihiro Shibutani, Izuho Hatada   +5 more
doaj   +1 more source

A simple marking system for accurate intraoperative monitoring and adjustment of cyclotorsion strabismus surgery

Frontiers in Medicine, 2023
Ocular cyclotorsion is treatable only with surgery. The surgical procedure must be tailored individually to the specific etiologies causing the horizontal and vertical strabismus and its torsional components. An adjustable surgical approach is often used
Lung-Chi Lee, Hsu-Chieh Chang, Hsu-Chieh Chang, Yi-Hao Chen, Ke-Hung Chien   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Spherical Steiner Symmetrizations

Axioms
In this paper, we primarily investigate and establish several properties of spherical Steiner symmetrizations, along with the isoperimetric property of the spherical cap in Sn.
Youjiang Lin, Zhilang Deng
doaj   +1 more source

I2-Cesàro summability of double sequences of sets

, 2020
In this paper, we defined concept of Wijsman I2-Cesàro summability and investigate the relationships between the concepts of Wijsman strongly I2-Cesàro summability, Wijsman strongly I2-lacunary convergence, Wijsman p-strongly I2-Cesàro summability andWijsman I2-statistical convergence of double sequences of sets.
Ulusu, Uğur, Dündar, Erdinç, Gülle, Esra   +2 more
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source