Results 51 to 60 of about 1,082,329 (323)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

On the Double Sequence Space Hϑ as an Extension of Hahn Space h

International Journal of Mathematics and Mathematical Sciences
Double sequence spaces have become a significant area of research within functional analysis due to their applications in various branches of mathematics and mathematical physics.
Orhan Tuǧ, Eberhard Malkowsky, Vladimir Rakoćević, Taja Yaying   +3 more
doaj   +1 more source

Matrix Transformations of Double Convergent Sequences with Powers for the Pringsheim Convergence

Mathematics
In 2004–2006, the corresponding double sequence spaces were defined for the Pringsheim and the bounded Pringsheim convergence by Gokhan and Colak. In 2009, Colak and Mursaleen characterized some classes of matrix transformations transforming the space of
Maria Zeltser, Şeyda Sezgek
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mean-Field approximation and Quasi-Equilibrium reduction of Markov Population Models

, 2014
Markov Population Model is a commonly used framework to describe stochastic systems. Their exact analysis is unfeasible in most cases because of the state space explosion.
Bortolussi, Luca, Paškauskas, Rytis
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multiplicity Results of Solutions to the Double Phase Problems of Schrödinger–Kirchhoff Type with Concave–Convex Nonlinearities

Mathematics, 2023
The present paper is devoted to establishing several existence results for infinitely many solutions to Schrödinger–Kirchhoff-type double phase problems with concave–convex nonlinearities.
Yun-Ho Kim, Taek-Jun Jeong
doaj   +1 more source

Dynamical Masses for Low-Mass Pre-Main Sequence Stars: A Preliminary Physical Orbit for HD 98800 B

, 2005
We report on Keck Interferometer observations of the double-lined binary (B) component of the quadruple pre-main sequence (PMS) system HD 98800. With these interferometric observations combined with astrometric measurements made by the Hubble Space ...
Andrew F. Boden, Anneila I. Sargent, Baraffe I., David R. Soderblom, David W. Latham, Ed Nelan, Guillermo Torres, Innes R., John M. Carpenter, Lawrence H. Wasserman, Otto G. Franz, Rachel L. Akeson, Siess L., Tokovinin A.   +13 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

On Ideal Convergent Difference Double Sequence Spaces in Intuitionistic Fuzzy Normed Linear Spaces

Universal Journal of Mathematics and Applications, 2021
In this paper, we introduce difference double sequence spaces ${I_{2} }^{(\mu,\upsilon)}(M,\Delta)$ and ${I_{2}^{0}}^{(\mu,\upsilon)}(M,\Delta)$ in the intuitionistic fuzzy normed linear spaces.
Esra Kamber, Selma Altundağ
doaj   +1 more source