Results 81 to 90 of about 31,082 (250)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Webbed spaces, double sequences, and the Macke convergence condition [PDF]

International Journal of Mathematics and Mathematical Sciences, 1999
In [3], Gilsdorf proved, for locally convex spaces, that every sequentially webbed space satisfies the Mackey convergence condition. In the more general frame of topological vector spaces, this theorem and its inverse are studied. The techniques used are double sequences and the localization theorem for webbed spaces.
openaire   +3 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Some New Double Sequence Spaces Defined by Orlicz Function in -Normed Space

Journal of Inequalities and Applications, 2011
The aim of this paper is to introduce and study some new double sequence spaces with respect to an Orlicz function, and also some properties of the resulting sequence spaces were examined.
Savaş Ekrem
doaj  

ν-wedge FDK-spaces [PDF]

Mathematica Moravica
The (weak) wedgeness for FK-spaces was first defined by Bennett in 1974. Then, some results of Bennett (1974) were improved by İnce (2002) and Daˇgadur (2004) for all (weak) wedge FK spaces.
Sezgek Şeyda, Dağadur İlhan
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Some generalized difference double sequence spaces defined by a sequence of Orlicz-functions

Cubo, 2012
In the present paper we introduce some generalized difference double sequence spaces defined by a sequence of Orlicz-functions. We study some topological properties and some inclusion relations between these spaces.
Kuldip Raj, Sunil K Sharma
doaj  

Almost convergent sequence spaces derived by the domain of quadruple band matrix

Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2020
In this work, we construct the sequence spaces f(Q(r,s,t,u)), f0(Q(r,s,t,u)) and fs(Q(r,s,t,u)), where Q(r,s,t,u) is quadruple band matrix which generalizes the matrices Δ3, B(r,s,t), Δ2, B(r,s) and Δ, where Δ3, B(r,s,t), Δ2, B(r,s) and Δ are called ...
Mustafa Cemil Bişgin
doaj