Results 121 to 130 of about 6,000 (194)

A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. [PDF]

, 2019
Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage.
Bier, Ethan, Kulkarni, Surashree S, Nizet, Victor, Valderrama, J Andrés   +3 more
core   +1 more source

Silencing the buzz: a new approach to population suppression of mosquitoes by feeding larvae double-stranded RNAs

Parasites & Vectors, 2015
Background Mosquito-borne diseases threaten over half the world’s human population, making the need for environmentally-safe mosquito population control tools critical.
Steve Whyard, Cassidy NG Erdelyan, Alison L Partridge, Aditi D Singh, Nigel W Beebe, Rupert Capina   +5 more
doaj   +1 more source

Evolution of the sex-determination gene Doublesex within the termite lineage

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics
ABSTRACTThe molecular mechanism of sex determination has long been considered conserved in insects. However, recent studies of hemimetabolous insects have challenged this notion. One notable example is termites. InReticulitermes speratus, a homolog of sex determination gene,Doublesex(RsDsx), exhibits characteristics that are distinct from those of ...
Kokuto Fujiwara, Satoshi Miyazaki, Kiyoto Maekawa   +2 more
openaire   +2 more sources

Learning recurrent representations for hierarchical behavior modeling [PDF]

, 2016
We propose a framework for detecting action patterns from motion sequences and modeling the sensory-motor relationship of animals, using a generative recurrent neural network.
Branson, Kristin, Eyjolfsdottir, Eyrun, Perona, Pietro, Yue, Yisong   +3 more
core   +2 more sources

Role of Dmrt5 during development of midbrain dopaminergic progenitors

, 2011
This thesis investigates the previously un-described role of Dmrt5, a zinc-finger transcription factor, in ventral midbrain development. The spatio-temporal expression pattern of Dmrt5, described for the first time in this thesis, suggests that Dmrt5 may
Farley, Emma Kirsten, Farley, Emma Kirsten   +1 more
core   +1 more source

Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi

Parasites & Vectors
Background Anopheles stephensi is a competent malaria vector mainly present in southern Asia and the Arabian Peninsula. Since 2012, it has invaded several countries of eastern Africa, creating an emerging risk of urban transmission.
Mireia Larrosa-Godall, Joshua X. D. Ang, Philip T. Leftwich, Estela Gonzalez, Lewis Shackleford, Katherine Nevard, Rob Noad, Michelle A. E. Anderson, Luke Alphey   +8 more
doaj   +1 more source

Profiling Doublesex-DNA interactions with targeted DamID in Drosophila melanogaster

, 2019
The transcriptional regulators doublesex (dsx) and fruitless (fru) function together to specify sexual physiology and behaviour in Drosophila melanogaster. Whilst fru has only been located in insect lineages, dsx is structurally and functionally conserved throughout the animal kingdom.
openaire   +1 more source

Arthropod genomics beyond fruit flies: bridging the gap between proximate and ultimate causation [PDF]

, 2016
Adams, Belles, Charlesworth, Clark, Emilia Santos, FLETCHER, Glastad, Gomes, Hasselmann, Ingram, Maderspacher, Misof, Pardue, Simon, Verhulst, Viljakainen, Wurm, Wurm   +17 more
core   +1 more source

Doublesex- and Mab-3-Related Transcription Factor 1 [PDF]

, 2020
openaire   +1 more source

A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae. [PDF]

Nat Commun
Strampelli A, Willis K, Gulliford HR, Gribble M, Fasulo B, Burt A, Crisanti A, Bernardini F.   +7 more
europepmc   +1 more source