Results 51 to 60 of about 1,257,306 (334)

Learning Highly Dynamic Skills Transition for Quadruped Jumping Through Constrained Space

Advanced Robotics Research, EarlyView.
A quadruped robot masters dynamic jumps through constrained spaces with animal‐inspired moves and intelligent vision control. This hierarchical learning approach combines imitation of biological agility with real‐time trajectory planning. Although legged animals are capable of performing explosive motions while traversing confined spaces, replicating ...
Zeren Luo, Jiahui Zhang, Yimin Han, Ji Ma, Minghao Lu, Ioannis Havoutis, Peng Lu   +6 more
wiley   +1 more source

PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores

BMC Bioinformatics, 2018
Background Polygenic risk scores (PRS) describe the genomic contribution to complex phenotypes and consistently account for a larger proportion of variance in outcome than single nucleotide polymorphisms (SNPs) alone.
Lawrence M. Chen, Nelson Yao, Elika Garg, Yuecai Zhu, Thao T. T. Nguyen, Irina Pokhvisneva, Shantala A. Hari Dass, Eva Unternaehrer, Hélène Gaudreau, Marie Forest, Lisa M. McEwen, Julia L. MacIsaac, Michael S. Kobor, Celia M. T. Greenwood, Patricia P. Silveira, Michael J. Meaney, Kieran J. O’Donnell   +16 more
doaj   +1 more source

Grip and Grasp: Lizard Claw Inspired Robotic Manipulators

Advanced Robotics Research, EarlyView.
Our study identifies the most effective lizard claw shape for use as an end effector in a bioinspired robotic manipulator. By examining key geometric features and combining them into comparative indices, the Crotaphytus collaris claw is found to be the best fit.
Hyeon Lee, Kate Douglas, Asyiah Bray, Andrea Rummel, Parvez Alam   +4 more
wiley   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Douglas–Rachford splitting for nonconvex optimization with application to nonconvex feasibility problems [PDF]

Mathematical programming, 2014
We adapt the Douglas–Rachford (DR) splitting method to solve nonconvex feasibility problems by studying this method for a class of nonconvex optimization problem.
Guoyin Li, Ting Kei Pong
semanticscholar   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2015
Hippocampal network activity is predominantly coordinated by -amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo ...
Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Ian eMahar, Ian eMahar, Ian eMahar, Maria Antonietta eDavoli, Maria Antonietta eDavoli, Jean-Guy eChabot, Jean-Guy eChabot, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Rémi eQuirion, Rémi eQuirion, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic   +20 more
doaj   +1 more source

Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice

Nature Communications, 2023
Initiating drug use during adolescence increases the risk of developing addiction or other psychopathologies later in life, with long-term outcomes varying according to sex and exact timing of use. The cellular and molecular underpinnings explaining this
Lauren M. Reynolds, Giovanni Hernandez, Del MacGowan, Christina Popescu, Dominique Nouel, Santiago Cuesta, Samuel Burke, Katherine E. Savell, Janet Zhao, Jose Maria Restrepo-Lozano, Michel Giroux, Sonia Israel, Taylor Orsini, Susan He, Michael Wodzinski, Radu G. Avramescu, Matthew Pokinko, Julia G. Epelbaum, Zhipeng Niu, Andrea Harée Pantoja-Urbán, Louis-Éric Trudeau, Bryan Kolb, Jeremy J. Day, Cecilia Flores   +23 more
doaj   +1 more source

Source identification of western Oregon Douglas-fir wood cores using mass spectrometry and random forest classification

Applications in Plant Sciences, 2017
Premise of the study: We investigated whether wood metabolite profiles from direct analysis in real time (time-of-flight) mass spectrometry (DART-TOFMS) could be used to determine the geographic origin of Douglas-fir wood cores originating from two ...
Kristen N. Finch, E. Espinoza, F., A. Jones, R. Cronn   +4 more
semanticscholar   +1 more source

Classification of Argyres-Douglas theories from M5 branes [PDF]

, 2015
We obtain a large class of new four-dimensional Argyres-Douglas theories by classifying irregular punctures for the six-dimensional (2, 0) superconformal theory of ADE type on a sphere. Along the way, we identify the connection between the Hitchin system
Y. Wang, Dan Xie
semanticscholar   +1 more source