Results 71 to 80 of about 3,003,698 (214)

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville   +6 more
wiley   +1 more source

CRESTED SHEAR CONNECTORS APPLICATION TO COMBINE REINFORCED CONCRETE SLAB AND PLANK-NAILED STRUCTURE OF BRIDGE SPAN

open access: yesВестник СибАДИ, 2020
Introduction. The construction of bridges using timber materials is experiencing a real boom throughout the world .The USA is considered to be a leader, where 80% of the bridges are made of timber or materials based on it.
V. A. Utkin, I. I. Gotovtsev
doaj   +1 more source

Experimental evaluation of self‐drilling dowels and densified wood dowels as connectors under shear and withdrawal for steel–timber composite beams

open access: yesce/papers, Volume 9, Issue 2-3, Page 1195-1201, September 2026.
Abstract I‐sections dominate conventional steel construction but exhibit direction‐dependent stability behavior, and in fire the steel's modulus of elasticity decreases rapidly. We therefore investigate a composite load‐bearing system in which the web cavities of I‐section beams are infilled with timber elements made of spruce glulam (GLT‐S) and beech ...
Robby Weiser   +2 more
wiley   +1 more source

Applied Element Modelling of Out‐Of‐Plane Instability in Boundary Elements of Thin RC Walls

open access: yesEarthquake Engineering &Structural Dynamics, Volume 55, Issue 11, Page 2800-2817, September 2026.
ABSTRACT Recent earthquakes in Chile (2010) and New Zealand (2011) caused extensive damage to buildings featuring reinforced concrete (RC) structural walls, with observed failure modes including out‐of‐plane instability of slender walls. This buckling‐type response under combined in‐plane and out‐of‐plane loading has also been documented in ...
Andrea Orgnoni   +2 more
wiley   +1 more source

Validity of Design Standards in Shear Strength of CFRP Concrete Member Without Shear Reinforcement

open access: yesBuildings
The shear design of concrete members reinforced with Carbon Fiber Reinforced Polymer (CFRP) bars remains a key hurdle for engineers. This study experimentally investigates the shear behavior of normal-strength concrete members reinforced with CFRP bars ...
So Yeong Choi, Il Sun Kim, Eun Ik Yang
doaj   +1 more source

Pull-Out Resistance Capacity of a New Perfobond Shear Connector for Steel Pile Cap Strengthening

open access: yesAdvances in Materials Science and Engineering, 2016
This study proposes a new type of the perfobond shear connector, which can be used to strengthen the steel pile cap embedded into the structure foundation, and evaluates its pull-out resistance capacity by performing a test on ten specimens.
Young-Ho Kim   +3 more
doaj   +1 more source

Effects of Wall‐to‐Floor Interactions on Seismic Response of Platform‐Type CLT Buildings

open access: yesEarthquake Engineering &Structural Dynamics, Volume 55, Issue 11, Page 2880-2896, September 2026.
ABSTRACT Platform‐type cross‐laminated timber (CLT) buildings feature discontinuous wall segments supported by CLT floors. In practice, CLT floors are often treated as rigid diaphragm, yet the wall‐to‐floor interactions (WFIs) associated with flexibility of floors remain insufficiently investigated during seismic performance assessment.
Chaoyue Zhang   +3 more
wiley   +1 more source

Performance of TGk dowel connector plates in wooden structure joints under long-term load

open access: yesMagazine of Civil Engineering
The article is devoted to the study of the bearing capacity and deformation of connections of wooden structures using plates with cylindrical TGk dowels of 5 mm diameter under prolonged load action.
Isupov Sergei
doaj   +1 more source

THE SECOND STAGE OF STRESSED-DEFORMED CONDITION OF REINFORCED CONCRETE STRUCTURES WHEN TURNING WITH BENDING (CASE 2)

open access: yesInternational Journal for Computational Civil and Structural Engineering, 2019
It is proposed a complex resistance computational model of reinforced concrete constructions in build­ings and structures under the action torsion with bending.
Vladimir Kolchunov   +2 more
doaj   +1 more source

Flexural behavior of FRP strengthened concrete-wood composite beams

open access: yesAin Shams Engineering Journal, 2018
An experimental investigation was conducted to study the structural performance of concrete-timber composite beams provided with systems of semi-rigid connectors of various configurations and stiffness.
Yehia A. Zaher Ali
doaj   +1 more source

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