Results 261 to 270 of about 4,698,937 (316)

Physiological and pathophysiological down-regulation of cough

Respiratory Physiology & Neurobiology, 2006
Recent clinical studies have emphasized the up-regulation (sensitization) of cough in pathological conditions of the airways. However there are also many situations where voluntary and reflex cough can be down-regulated. These include: (1) chemical stimulation of breathing by hypercapnia or hypoxia or both, establishing that cough sensitivity can be ...
John, Widdicombe, Vijay, Singh
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Down-regulation of MeCP2 in Hirschsprung's disease

Journal of Pediatric Surgery, 2013
Hirschsprung's disease (HSCR) is a congenital disorder characterized by the absence of intramural ganglion cells which are highly associated with impaired proliferation and migration of neural crest cells. Whether methyl CpG binding protein 2 (MeCP2) is related with HSCR still remains unknown.
Zhigang, Zhou, Jingjing, Qin, Junwei, Tang, Bo, Li, Qiming, Geng, Weiwei, Jiang, Wei, Wu, Virender, Rehan, Weibing, Tang, Xiaoqun, Xu, Yankai, Xia   +10 more
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CD8 is down(regulated) for tolerance

Trends in Immunology
Activated CD8+ T cells directly kill target cells. Therefore, the regulation of their function is central to avoiding immunopathology. Mechanisms that curb effector functions in CD4+ and CD8+ T cells are mostly shared, yet important differences occur.
Noé Rodríguez-Rodríguez, Florencia Rosetti, José C. Crispín   +2 more
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Hepcidin Is Down‐Regulated in Alcohol Loading

Alcoholism: Clinical and Experimental Research, 2007
Background: It is common for alcoholic patients to have excess iron accumulation in the liver, which may contribute to the development of alcoholic liver disease (ALD). However, the mechanism of hepatic iron uptake in ALD is still obscure. Recently, a novel iron‐regulatory hormone hepcidin was found that suppresses the absorption of iron from the ...
Takaaki, Ohtake, Hiroyuki, Saito, Yayoi, Hosoki, Mitsutaka, Inoue, Shigeki, Miyoshi, Yasuaki, Suzuki, Yoshinori, Fujimoto, Yutaka, Kohgo   +7 more
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Probiotics and down-regulation of the allergic response

Immunology and Allergy Clinics of North America, 2004
The first clinical trials with probiotics, especially in the treatment of atopic eczema, have yielded encouraging results. Experimental studies have found that probiotics exert strain-specific effects in the intestinal lumen and on epithelial cells and immune cells with anti-allergic potential.
Marko A, Kalliomäki, Erika, Isolauri
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Down-regulation of Dicer in hepatocellular carcinoma

Medical Oncology, 2010
Dicer, the key enzyme in the RNAi pathway, is misregulated in tumor tissues. The altered expression of Dicer is associated with clinical characteristics in patients with cancer. Liver carcinoma and adjacent non-neoplastic tissues were obtained from 36 patients with hepatocellular carcinoma (HCC) undergoing surgery.
Jin-Feng, Wu, Wei, Shen, Nian-Zhou, Liu, Gui-Li, Zeng, Mei, Yang, Guo-Qing, Zuo, Xiu-Ni, Gan, Hong, Ren, Kai-Fu, Tang   +8 more
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Hippocampal ripples down-regulate synapses

Science, 2018
Rebalancing mechanisms during sleep Synapses are often strengthened during wake periods and thus need to be homeostatically readjusted during sleep. During slow-wave sleep, synaptic depression is dominant. Sharp wave and ripple events are transient high-frequency field oscillations that occur spontaneously during slow-wave sleep ...
Hiroaki Norimoto, Kenichi Makino, Mengxuan Gao, Yu Shikano, Kazuki Okamoto, Tomoe Ishikawa, Takuya Sasaki, Hiroyuki Hioki, Shigeyoshi Fujisawa, Yuji Ikegaya   +9 more
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Down Regulation of Fc Receptors by IVIgG

International Reviews of Immunology, 1989
IVIgG preparations are now widely applied for immune modulatory treatment in various forms of autoimmune and immune complex diseases. Several controlled studies clearly demonstrated the clinical efficacy of this type of treatment; the underlying pathophysiological mechanisms, however, have yet to be elucidated.
J W, Mannhalter, M M, Eibl
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Down-Regulation of gp130 in Nasopharyngeal Carcinoma

American Journal of Rhinology & Allergy, 2009
Background The purpose of this study was to explore the expression and biological functions of glycoprotein 130 (gp130) in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC). A prospective study was performed. Methods
Yung-Song, Lin, Li-Ching, Lin, Mei-Hui, Huang, Ai-Ju, Huang, Yu-Tzu, Huang   +4 more
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Down-regulation of the down-regulated in adenoma (DRA) gene correlates with colon tumor progression.

Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
The down-regulated in adenoma (DRA) gene was originally identified as a gene that was down-regulated in colon tumors. It encodes a protein with anion transporter function that is expressed predominantly in the mucosa of the lower gastrointestinal tract. In this study, expression of DRA and its cellular distribution have been investigated in a series of
Antalis, Toni M., Reeder, Jennifer A., Gotley, David C., Byeon, Mee Kyeong, Walsh, Michael D., Henderson, Kelly W., Papas, Takis S., Schweinfest, Clifford W.   +7 more
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