Results 1 to 10 of about 25,321,967 (307)

Up-regulation of key glycolysis proteins in cancer development

Open Life Sciences, 2018
In rapid proliferating cancer cells, there is a need for fast ATP and lactate production, therefore cancer cells turn off oxidative phosphorylation and turn on the so called "Warburg effect". This regulating the expression of genes involved in glycolysis.
Nowak Nicole, Kulma Anna, Gutowicz Jan
doaj   +2 more sources

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.

PLoS Biology, 2019
Cellular senescence is a driver of various aging-associated disorders, including osteoarthritis. Here, we identified a critical role for Yes-associated protein (YAP), a major effector of Hippo signaling, in maintaining a younger state of human ...
Lina Fu, Yuqiong Hu, Moshi Song, Zunpeng Liu, Weiqi Zhang, Fa-Xing Yu, Jun Wu, Si Wang, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Fuchou Tang, Guang-Hui Liu   +12 more
doaj   +2 more sources

Up-regulation of SLC26A3 enhances oxaliplatin sensitivity in colorectal cancer [PDF]

Discover Oncology
The role of SLC26A3 in the sensitivity to oxaliplatin, a widely used chemotherapy drug for colorectal cancer (CRC), remains unclear. This study aimed to explore the association between SLC26A3 expression and oxaliplatin sensitivity.
Junyang Wang, Shaodong Tang, Min Zhang, Songhe Li, Dacheng Wen   +4 more
doaj   +2 more sources

The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, 2023
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu, Qi Chen, Xiao-Jie Chen, Feng Han, Zhong Chen, Yi Wang   +5 more
semanticscholar   +1 more source

Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy

New England Journal of Medicine, 2022
BACKGROUND Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated.
Yao-Chung Liu, J. Kwon, E. Fabiani, Zhijian Xiao, Yanjing V. Liu, M. Follo, Jinqin Liu, Huijun Huang, Chong Gao, J. Liu, G. Falconi, Lia Valentini, C. Gurnari, C. Finelli, L. Cocco, Jin-Hwang Liu, Adrianna I Jones, Jun-Yu Yang, Henry Yang, J. Thoms, Ashwin Unnikrishnan, J. Pimanda, Rongqing Pan, M. Bassal, M. Voso, D. Tenen, L. Chai   +26 more
semanticscholar   +1 more source

Everolimus-induced somatostatin receptor overexpression in a rectal neuroendocrine tumor patient may promote somatostatin receptor-guided radionuclide therapy (peptide receptor radiotherapy) as an additional treatment option

World Journal of Nuclear Medicine, 2021
We present a case of Grade II, well-differentiated rectal neuroendocrine tumor in a 39-year-old patient. Following different sequential treatment modalities, the disease progressed both on metabolic (18F-fluorodeoxyglucose positron emission tomography ...
Magdalena Mileva, Zéna Wimana, Patrick Flamen, Ioannis Karfis   +3 more
doaj   +1 more source

Up-Regulation of CD146 in Schwann Cells Following Peripheral Nerve Injury Modulates Schwann Cell Function in Regeneration

Frontiers in Cellular Neuroscience, 2021
CD146 is cell adhesion molecule and is implicated in a variety of physiological and pathological processes. However, the involvement of CD146 in peripheral nerve regeneration has not been studied yet.
Yinying Shen, Jun Zhu, Qianyan Liu, Shiyan Ding, Xinpeng Dun, Jianghong He   +5 more
doaj   +1 more source

Uneven Expression of 20 Human Papillomavirus Genes Associated with Oropharyngeal Carcinoma Ali Adel Dawood

Rambam Maimonides Medical Journal, 2023
Background: Human papillomavirus HPV is considered to be responsible for 95% of virus-related cancers in many organs. Oropharyngeal carcinoma (OC) is distinguished by the transformation of the healthy epithelium into precancerous cells.
Ali Adel Dawood
doaj   +1 more source

Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation

Science Advances, 2020
Rapid up-regulation of endogenous mechanoresponsive genes by force depends on demethylation of histone H3 lysine-9 trimethylation. Mechanical forces play important roles in development, physiology, and diseases, but how force is transduced into gene ...
Jian Sun, Junwei Chen, E. Mohagheghian, Ning Wang   +3 more
semanticscholar   +1 more source

Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line

Cell & Bioscience, 2021
Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively alter transcriptome, the proteome of ...
Sen Yuan, Yousaf Tanzeel, Xuezhang Tian, Dandan Zheng, Naz Wajeeha, Jiaqi Xu, Yujia Ke, Zuopeng Zhang, Xiaojun Peng, Long Lu, Guihong Sun, Deyin Guo, Min Wang   +12 more
doaj   +1 more source