Results 1 to 10 of about 4,698,937 (316)
Stress-Induced Down-Regulation of CPEB4 Disrupts Sodium Channel Regulation and Myocardial Excitability [PDF]
JACC: Basic to Translational ScienceSummmary: Unstable ion channel mRNAs contribute to electrical remodeling and arrhythmic risk in heart failure. CPEB4 promotes cytoplasmic polyadenylation and stabilizes target mRNAs, thereby supporting translation.
Gyeoung-Jin Kang, PhD +4 more
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Frontiers in Endocrinology, 2021 Backgrounddown-regulation has been widely used in IVF treatment; however, it lacks reports on the impact of down-regulation on obstetrics and perinatal outcomes.
Lei Jin +5 more
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Rambam Maimonides Medical Journal, 2023 Background: Human papillomavirus HPV is considered to be responsible for 95% of virus-related cancers in many organs. Oropharyngeal carcinoma (OC) is distinguished by the transformation of the healthy epithelium into precancerous cells.
Ali Adel Dawood
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Protein Kinase C Life Cycle: Explained Through Systems Biology Approach
Frontiers in Physiology, 2022 Protein kinase C (PKC) enzymes are a family of kinases that mediate signal transduction originating at the cell surface. Most cell membranes can contain functional PKC enzymes.
Naveed Aslam, Farah Alvi, Farah Alvi
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Motivated Down-Regulation of Emotion and Compassion Collapse Revisited
Frontiers in Psychology, 2022 Compassion collapse is a phenomenon where feelings and helping behavior decrease as the number of needy increases. But what are the underlying mechanisms for compassion collapse? Previous research has attempted to pit two explanations: Limitations of the
William Hagman +11 more
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Mechanism for down‐regulation of CD28 by Nef [PDF]
The EMBO Journal, 2001 SIV and HIV Nef proteins disrupt T-cell receptor machinery by down-modulating cell surface expression of CD4 and expression or signaling of CD3-TCR. Nef also down-modulates class I major histocompatibility complex (MHC) surface expression. We show that SIV and HIV-1 Nefs down-modulate CD28, a major co-stimulatory receptor that mediates effective T-cell
T, Swigut, N, Shohdy, J, Skowronski
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Alteration of miR-21 and miR-24 expression: biomarker for early detection of synchronous metastases in colorectal cancer: a cross-sectional study in Indonesia [PDF]
Intestinal ResearchBackground/Aims Timely detection with highly accurate biomarkers would be helpful in effectively managing colorectal cancer (CRC). We aim to investigate the accuracy of 3 emerging biomarkers—miR-21, miR-24, and miR-145—in detecting synchronous metastases
Yudith Annisa Ayu Rezkitha +7 more
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SOX7 is down-regulated in lung cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2013 Abstract Background SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown. Methods In this study, whole genomic copy number analysis was performed on a series of non-small cell lung cancer (NSCLC) cell lines and samples from ...
Hayano, T. +12 more
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Chronic Diseases Journal, 2018 BACKGROUND: Angiogenesis is vital for development of normal tissue and wound healing; but it play an important role in development of some diseases such as different types of cancer.
Esmaeil Rahimi +2 more
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Cell & Bioscience, 2021 Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively alter transcriptome, the proteome of ...
Sen Yuan +12 more
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