Results 41 to 50 of about 4,698,937 (316)

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

AppliedChem
The multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention.
Bruna Henrique Teixeira, Karina de Oliveira Gonçalves, Daniel Perez Vieira, Lilia Coronato Courrol   +3 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Electricity network regulation in the EU : The challenges ahead‎ for transmission and distribution

, 2018
The UK model of incentive regulation of power grids was at one time the most advanced, and elements of it were adopted throughout the EU. This model worked well, particularly in the context of limited investment and innovation, a single and strong ...

core   +1 more source

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

Frontiers in Molecular Neuroscience, 2018
Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan, Liang Ren, Lulan Chen, Guoxiang Wang, Xu Liu, Benjamin H. Wang, Yun Wang   +6 more
doaj   +1 more source

Tollip-induced down-regulation of MARCH1

Results in Immunology, 2013
In addition to their classical antigen presenting functions, MHC class II molecules potentiate the TLR-triggered production of pro-inflammatory cytokines. Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
Bourgeois-Daigneault, Marie-Claude, Pezeshki, Abdul Mohammad, Galbas, Tristan, Houde, Mathieu, Baril, Martin, Früh, Klaus, Amrani, Abdelaziz, Ishido, Satoshi, Lamarre, Daniel, Thibodeau, Jacques   +9 more
openaire   +2 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

La atención médica al adulto con síndrome de Down [PDF]

, 2012
Recomendaciones sobre hábitos saludables, especialistas a los que es imprescindible visitar, vacunaciones, la etapa del envejecimiento, cuestiones como el alzhéimer o la salud mental.
Down España
core  

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Manual sobre voluntariado con personas con síndrome de Down

, 2020
El presente manual tiene como propósito ofrecer información básica a las personas que de forma solidaria y altruista desean realizar tareas de voluntariado con personas con síndrome de Down dentro de las entidades que conforman Down ...
Down España
core  

Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type

Chinese Journal of Lung Cancer, 2011
Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth.
Yongkai WU, Ting XIAO, Min LI, Ying ZHANG, Yanning GAO, Kelin SUN   +5 more
doaj   +1 more source