Results 61 to 70 of about 4,698,937 (316)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Envejecer con síndrome de Down: una realidad que plantea nuevos retos [PDF]
, 2012 El curso "El envejecimiento de las personas con discapacidad intelectual", organizado del 22 al 26 de septiembre por la Universidad Internacional del Mar, en colaboración con Down España y Fundown, abordó las cuestiones principales de esta etapa vital ...
Salvador, Martínez +3 more
core
Down-regulation of invasion-related pathway and alteration of AP2 genes in domain deletion mutants.
, 2021 (A) Heatmaps displaying down-regulation of genes involved in the invasion of the RBC in the two deletion mutants. * and # indicate the AP2-I and putative AP2-LT target genes, respectively.
Amuza Byaruhanga Lucky (3216390) +8 more
core +1 more source
LPS Down-Regulates Specificity Protein 1 Activity by Activating NF-κB Pathway in Endotoxemic Mice. [PDF]
PLoS ONE, 2015 Specificity protein (Sp) 1 mediates the transcription of a large number of constitutive genes encoding physiological mediators. NF-κB mediates the expression of hundreds of inducible genes encoding pathological mediators.
Xiaobing Ye +3 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
La necesidad de legislar la información a familias que esperan un hijo con síndrome de Down [PDF]
, 2012 Desde hace ya algún tiempo tanto los profesionales como las asociaciones demandan planes de actuación que humanicen la forma en que los padres reciben la noticia pre y/o posnatal de la existencia de un niño con síndrome de Down.
Linares von Schmiterlöw, Carmen
core
Diabetic HDL is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of SR-BI expression. [PDF]
PLoS ONE, 2012 Diabetic HDL had diminished capacity to stimulate endothelial cell (EC) proliferation, migration, and adhesion to extracellular matrix. The mechanism of such dysfunction is poorly understood and we therefore sought to determine the mechanistic features ...
Bing Pan +14 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Journal of Pharmacological Sciences, 2006 .: Histamine H1 receptor (H1R) signaling is regulated by changing its expression level. Two mechanisms are involved in this regulation. One is down-regulation through receptor desensitization.
Miyoshi Katsuhiro +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source