Results 71 to 80 of about 4,698,937 (316)
Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype
Journal of Pharmacological Sciences, 2004 Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi +5 more
doaj +1 more source
Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase. [PDF]
PLoS ONE, 2011 Retinoids are mostly stored as retinyl esters in hepatic stellate cells (HSCs) through esterification of retinol and fatty acid, catalyzed by lecithin-retinol acyltransferase (LRAT). This study is designated to address how retinyl esters are mobilized in
Yujiro Kida +9 more
doaj +1 more source
Optimal Down Regulation of mRNA Translation
Scientific Reports, 2017 AbstractDown regulation of mRNA translation is an important problem in various bio-medical domains ranging from developing effective medicines for tumors and for viral diseases to developing attenuated virus strains that can be used for vaccination. Here, we study the problem of down regulation of mRNA translation using a mathematical model called the ...
Yoram Zarai +2 more
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2018 To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray.
Nobuaki Hanawa (4901986) +5 more
core +1 more source
Effect of CXCR4 on Apoptosis in Osteosarcoma Cells via the PI3K/Akt/NF-κβ Signaling Pathway
Cellular Physiology and Biochemistry, 2018 Background/Aims: Osteosarcoma, the most common primary bone malignancy, arises from primitive transformed cells of mesenchymal origin with the worldwide increasing morbidity and mortality.
Chunming Jiang +8 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
La vida sexual y afectiva de las personas con síndrome de Down [PDF]
, 2012 Las personas con síndrome de Down tienen, sienten y pueden practicar su sexualidad. Los profesionales, padres o familia deben captar sus deseos en todas las áreas, incluida la sexual, para que puedan ser escuchadas, atendidas y en lo posible satisfechas.
Garvía, Beatriz, Miquel, Mª José
core
Down-regulation of Androgen-Responsive Gene Expression by TQ and AT.
, 2016 Down-regulation of Androgen-Responsive Gene Expression by TQ and AT.
John K. Scariano (3176454) +5 more
core +1 more source
Down-Regulation of miR-3928 Promoted Osteosarcoma Growth
Cellular Physiology and Biochemistry, 2014 Background: Osteosarcoma is the most common primary bone malignancy in children and young adults. Most failures of osteosarcoma treatment were due to resistance to chemotherapy.
Haidong Xu, Xiaozhou Liu, Jianning Zhao
doaj +1 more source