Results 11 to 20 of about 4,698,937 (316)

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

open access: yeseLife, 2021
Attachment of ubiquitin (Ub) to cell surface proteins serves as a signal for internalization via clathrin-mediated endocytosis (CME). How ubiquitinated membrane proteins engage the internalization apparatus remains unclear.
Natalya Pashkova   +7 more
doaj   +1 more source

Down-Regulation of Testicular Aromatization in the Horse [PDF]

open access: yesBiology of Reproduction, 1989
A single i.m. injection of testosterone (750 mg of testosterone bexahydrobenzoate) or i.v. injection of human chorionic gonadotrophin (hCG) (10,000 IU) was given to geldings and stallions. Levels of unconjugated and conjugated (after solvolysis) androgens and estrogens were measured in blood and urine samples taken daily from the day of injection (D0 ...
I, Zwain   +3 more
openaire   +2 more sources

Study on microRNA-9-5p reducing sensitivity of breast cancer cells to doxorubicin through targeting HIC1 [PDF]

open access: yesWaike lilun yu shijian, 2020
Objective To study the effect of microRNA-9-5p (miR-9-5p) which regulate hypermethylated in cancer 1 (HIC1) in reducing sensitivity of breast cancer MDA-MB-231 cells to doxorubicin (DOX) and the mechanisms.
GAO Hang, ZHAO Feng, WU Yan, PEI Wenjiang, ZHONG Ming, GU Yan, GUO Shanyu, DAI Qiancheng, ZHANG Wei
doaj   +1 more source

Species-specific morphological and physiological characteristics and progressive nitrogen limitation under elevated CO2 concentration

open access: yesiForest - Biogeosciences and Forestry, 2020
Elevated atmospheric CO2 (eCO2) concentration initially enhances photosynthesis, growth and ecosystem productivity, but the excessive use of nitrogen due to the increased productivity causes uncertainty in long-term ecosystem responses. We exposed Korean
Song WK   +8 more
doaj   +1 more source

HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity

open access: yesRetrovirology, 2023
Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined.
Delon Naicker   +9 more
doaj   +1 more source

N-myc Down-Regulates Activin A

open access: yesBiochemical and Biophysical Research Communications, 2000
N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily.
Breit, Stephen   +3 more
openaire   +4 more sources

Down-regulation of Delta by proteolytic processing [PDF]

open access: yesThe Journal of Cell Biology, 2002
Notch signaling regulates cell fate decisions during development through local cell interactions. Signaling is triggered by the interaction of the Notch receptor with its transmembrane ligands expressed on adjacent cells. Recent studies suggest that Delta is cleaved to release an extracellular fragment, DlEC, by a mechanism that involves the activity ...
Mishra-Gorur, Ketu   +3 more
openaire   +2 more sources

ESTs analysis in maize developing kernels exposed to single and combined water and heat stresses Análise de ESTs de espigas de milho em desenvolvimento expostas a estresse simples e combinado de água e calor

open access: yesScientia Agricola, 2011
Molecular and metabolic response of plants to a combination of two abiotic stresses is unique and cannot be directly extrapolated from the response of plants to each of the stresses individually.
Violeta Andjelković   +1 more
doaj   +1 more source

A novel treatment approach for retinoblastoma by targeting epithelial growth factor receptor expression with a shRNA lentiviral system [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2017
Objective(s): Non-invasive treatment options for retinoblastoma (RB), the most common malignant eye tumor among children, are lacking. Epithelial growth factor receptor (EGFR) accelerates cell proliferation, survival, and invasion of many tumors ...
Yong Chai   +6 more
doaj   +1 more source

Eyes-Closed Resting EEG Predicts the Learning of Alpha Down-Regulation in Neurofeedback Training

open access: yesFrontiers in Psychology, 2018
Neurofeedback training, which enables the trainee to learn self-control of the EEG activity of interest based on online feedback, has demonstrated benefits on cognitive and behavioral performance.
Wenya Nan   +6 more
doaj   +1 more source

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