Results 291 to 300 of about 5,393,020 (341)

Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson's disease. [PDF]

Front Neurosci
Favaro M, Mauri S, Bernardo G, Zordan MA, Mazzotta GM, Ziviani E.   +5 more
europepmc   +1 more source

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BASP1 down-regulates RANKL-induced osteoclastogenesis

Experimental Cell Research, 2023
The cytokine RANKL (Receptor Activator of NFκB Ligand) is the key driver of differentiation of monocytes/macrophages to form multi-nucleated, bone-resorbing osteoclasts, a process that is accompanied by significant changes in gene expression. We show that exposure to RANKL rapidly down-regulates expression of Brain Acid Soluble Protein 1 (BASP1) in ...
Anuj Anuj, Nina Reuven, Stefan G.E. Roberts, Ari Elson   +3 more
openaire   +2 more sources

REDUNDANT DOWN-REGULATION PATHWAYS FOR p53 [PDF]

Pharmacological Research, 1998
The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and active p53 isoforms.
CINELLI, MARINA, MAGNELLI, LUCIA, CHIARUGI, VINCENZO   +2 more
openaire   +2 more sources

Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.

ACS Chemical Neuroscience, 2019
N6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in the mRNA of eukaryotes and plays a vital role in the post-transcriptional regulation.
Xuechai Chen, Chunyu Yu, M. Guo, Xiaotong Zheng, Sakhawat Ali, Hua Huang, Lihua Zhang, Shensen Wang, Yinghui Huang, Shuyan Qie, Juan Wang   +10 more
semanticscholar   +1 more source

Hippocampal ripples down-regulate synapses

Science, 2018
Rebalancing mechanisms during sleep Synapses are often strengthened during wake periods and thus need to be homeostatically readjusted during sleep. During slow-wave sleep, synaptic depression is dominant. Sharp wave and ripple events are transient high-frequency field oscillations that occur spontaneously during slow-wave sleep ...
Hiroaki Norimoto, Kenichi Makino, Mengxuan Gao, Yu Shikano, Kazuki Okamoto, Tomoe Ishikawa, Takuya Sasaki, Hiroyuki Hioki, Shigeyoshi Fujisawa, Yuji Ikegaya   +9 more
openaire   +2 more sources

Down regulation in hypersensitivity pneumonitis

Journal of Allergy and Clinical Immunology, 1990
Levels of soluble interleukin-2 receptor (sol-IL-2R) in the bronchoalveolar lavage fluid (BALF) of pigeon breeders with hypersensitivity pneumonitis were compared with BALF levels in asymptomatic pigeon breeders who had been exposed to pigeon allergens for an equivalent length of time.
J H, Edwards, S P, Reynolds, K P, Jones, B H, Davies   +3 more
openaire   +2 more sources