Results 171 to 180 of about 453,301 (335)

TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p

, 2020
Shanshan Li, Yixin Yin, Liping Yao, Ziyi Lin, Shengjun Sun, Jin Zhang, Xiaoyan Li   +6 more
openalex   +2 more sources

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Temporal dynamics of gene and protein signatures following volumetric muscle loss

Frontiers in Cell and Developmental Biology
IntroductionVolumetric muscle loss (VML) is characterized by permanent tissue impairment resulting from critically-sized muscle loss. We performed time-series transcriptomic and proteomic analyses to reveal key mediators of irreversible pathological ...
Ishita Jain, Ishita Jain, Ishita Jain, Beu P. Oropeza, Beu P. Oropeza, Beu P. Oropeza, Caroline Hu, Gladys Chiang, Sree Aravindan, Renato Reyes, Daniel Yuhang Li, Paul Cheng, Paul Cheng, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang   +17 more
doaj   +1 more source

Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1

, 2012
Andreea M. Bujor, Paul Haines, Cristina M. Padilla, Romy Christmann, Lia Monica Junie, Percival D. Sampaio‐Barros, Robert Lafyatis, Maria Trojanowska   +7 more
openalex   +2 more sources

Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins [PDF]

, 2022
Elisa De Tomi, Rachele Campagnari, Elisa Orlandi, Alessia Cardile, Valentina Zanrè, Marta Menegazzi, Macarena Gomez‐Lira, Giovanni Gotte   +7 more
openalex   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Arecoline induces dual modulation of blood pressure in rat, including an initial downregulation and a subsequent upregulation

, 2020
Jiashan Wu, Lijuan Chen, Meiping Deng, Xiaowen Ye, Jiang Xiao-xia, Jiangliu Fu, Peiling Zhou, Changzheng Zhang   +7 more
openalex   +2 more sources

Upregulation of miRNA-202 promotes apoptosis and inhibits migration of glioma cell line via downregulation of ROCK1 gene [PDF]

, 2020
Mousa Behzadi, Hamed Hatami, Fatemeh Alian, Maryam Shojaee, Masoumeh Alimohammadi, Shahin Alizadeh‐Fanalou, Jafar Karami   +6 more
openalex   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source